JAHA:血清Vaspin作为急性心肌梗死不良心脏事件的预测因子

2019-01-16 xing.T MedSci原创

由此可见,该研究表明血清Vaspin水平是AMI​​患者MACE的重要预后指标。

已有文献报道了内脏脂肪组织来源的丝氨酸蛋白酶抑制剂(Vaspin)参与动脉粥样硬化性血管疾病的发展。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在探讨急性心肌梗死(AMI)患者血清Vaspin的预后价值。

研究人员在一项队列研究中纳入了1036名AMI患者,并使用Cox回归分析确定了血清Vaspin与主要不良心脏事件(MACE)之间的关联。

受试者工作特征曲线表明血清Vaspin可显著区分MACE患者,最佳临界值为0.62 ng/mL。Kaplan-Meier生存曲线显示Vaspin水平较低的患者MACE发生率较高。多变量Cox回归分析显示低Vaspin水平是MACE的独立预测因子(风险比为0.74; 95%CI为0.48-0.96; P=0.029),与年龄; AMI、心力衰竭、高血压糖尿病既往病史;Killip分级;血管重建术; CRP(C-反应蛋白)和NT-proBNP(B型利尿钠肽前体N-末端)一致。通过在传统危险因素模型中加入Vaspin可显著改善MACE的综合判别和净重分类改善。此外,调整常规的心血管危险因素后,低Vaspin是心力衰竭住院(风险比为0.58; 95%CI为0.37-0.89; P=0.005)和复发性AMI(风险比为0.72; 95%CI为0.53-0.95; P=0.036 )的重要预测因子。

由此可见,该研究表明血清Vaspin水平是AMI​​患者MACE的重要预后指标。

原始出处:

Xiang Zhou.et al.Serum Vaspin as a Predictor of Adverse Cardiac Events in Acute Myocardial Infarction.JAHA.2019.https://www.ahajournals.org/doi/full/10.1161/JAHA.118.010934

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2019-02-24 HNYYM
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    2019-01-18 zhaohui6731

    #AHA#

    0

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    2019-01-18 宋威
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    2019-01-17 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0