Tocilizumab和sarilumab降低了COVID-19重症患者的死亡风险

2021-01-08 Allan MedSci原创

近日,REMAP CAP研究发现,Tocilizumab和sarilumab可将COVID-19重症患者的死亡率降低8.5%,还可以缩短患者的康复时间。

近日,REMAP CAP研究发现,Tocilizumab和sarilumab可将COVID-19重症患者的死亡率降低8.5%,还可以缩短患者的康复时间。Tocilizumab和sarilumab还使重症患者在ICU花费的时间减少了约一周。英国卫生部长Matt Hancock说:“这项结果是摆脱COVID-19大流行的又一个里程碑式进展,当将其添加到已经推出的疫苗和治疗方法中时,它们将在战胜COVID-19过程中发挥重要作用”。

REMAP CAP研究涉及来自英国等六个国家的约800例重症患者。另一项研究(RECOVERY试验)先前发现,地塞米松使COVID-19重症患者的死亡率减少了三分之一。据英国广播公司的报道,与Tocilizumab和sarilumab相比,地塞米松的成本相对较低(每疗程约5英镑),而Tocilizumab和sarilumab的成本约为750-1000英镑。

但是,REMAP CAP研究的首席研究员Anthony Gordon教授评论说:“Tocilizumab和sarilumab在挽救患者生命方面具有巨大优势”。

 

原始出处:

http://www.pharmatimes.com/news/tocilizumab_and_sarilumab_cut_risk_of_death_in_severe_covid-19_patients_1360960

评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1912510, encodeId=8a4d1912510ac, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Oct 01 01:21:58 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256042, encodeId=337812560420f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284115, encodeId=ed861284115d7, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914974, encodeId=02289149e4a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 20:18:09 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-10-01 snf701207
  2. [GetPortalCommentsPageByObjectIdResponse(id=1912510, encodeId=8a4d1912510ac, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Oct 01 01:21:58 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256042, encodeId=337812560420f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284115, encodeId=ed861284115d7, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914974, encodeId=02289149e4a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 20:18:09 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1912510, encodeId=8a4d1912510ac, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Oct 01 01:21:58 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256042, encodeId=337812560420f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284115, encodeId=ed861284115d7, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914974, encodeId=02289149e4a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 20:18:09 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1912510, encodeId=8a4d1912510ac, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Oct 01 01:21:58 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256042, encodeId=337812560420f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284115, encodeId=ed861284115d7, content=<a href='/topic/show?id=cdb79594643' target=_blank style='color:#2F92EE;'>#重症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95946, encryptionId=cdb79594643, topicName=重症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Sun Jan 10 12:21:58 CST 2021, time=2021-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914974, encodeId=02289149e4a7, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 09 20:18:09 CST 2021, time=2021-01-09, status=1, ipAttribution=)]

相关资讯

Arthritis Rheumatol:Tocilizumab可有效治疗JIA相关葡萄膜炎

近期有研究称,对于重症幼年特发性关节炎相关的葡萄膜炎、既往常规免疫抑制药物和至少一种抗肿瘤坏死因子剂治疗失败的患者,Tocilizumab治疗是有效的。 研究人员进行了一项多中心研究,纳入了25例重症幼年特发性关节炎相关的葡萄膜炎、既往常规免疫抑制药物和至少一种抗肿瘤坏死因子剂治疗失败的患者,治疗药物包括阿达木单抗(n = 24)、依那西普(n =8)、英夫利昔单抗(n =7)、阿巴西普(n

NEJM:Tocilizumab用于新冠肺炎住院患者的治疗

Tocilizumab治疗不能降低新冠肺炎患者插管或死亡风险

2019年ARVO:Tocilizumab显著减少巨细胞动脉炎的发作次数

根据2019年视觉和眼科学研究协会年会(ARVO)的一项回顾性分析结果,Tocilizumab的治疗与巨细胞动脉炎(GCA)患者的发作次数的显著减少有关。

喜讯!FDA授予罗氏抗炎药Actemra/RoActemra第2个突破性药物资格,治疗巨细胞动脉炎(GCA)

瑞士制药巨头罗氏(Roche)抗炎药Actemra/RoActemra(tocilizumab,托珠单抗)近日在美国监管方面传来喜讯。FDA已授予Actemra/RoActemra治疗巨细胞动脉炎(GCA)的突破性药物资格(BTD),这也是该药在美国监管方面获得的第2个突破性药物资格,之前,FDA于2015年6月授予该药治疗系统性硬化症(SSc)的BTD。值得一提的是,此次BTD,也是罗氏自2

Lancet respirat med:托珠单抗治疗系统性硬化症的3期临床试验结果

托珠单抗(tocilizumab)是一种抗白介素6受体抗体,已有的2期试验提示其在系统性硬化症中具有一定疗效。本研究进一步开展了一项随机对照3期试验,以评估托珠单抗系统性硬化症的疗效和安全性。

Lancet Rheumatol:重症监护室的COVID-19患者采用Tocilizumab治疗对预后的影响

Tocilizumab,是一种靶向白介素-6受体的单克隆抗体,有人认为它或可减轻重度COVID-19相关的细胞因子风暴综合征。本研究旨评估该药物对重症COVID-19患者预后的影响。

拓展阅读

【今日分享】2025 NICE 指南:COVID-19快速指南:COVID-19的管理 [NG191]

本指南涵盖了在社区和医院环境中管理婴儿、儿童、青少年和成人的新冠病毒。它包括关于沟通、评估、新冠病毒的治疗、无创呼吸支持、预防和管理急性并发症以及识别和管理合并感染的建议。

JAMA Netw Open:COVID-19大流行对儿童呼吸道病原体检测率的影响

儿童呼吸道病原体检测率在COVID-19大流行期间显著上升且持续高位,急诊组检测率增幅尤为突出。

Pediatrics:COVID-19大流行期间儿童胆囊切除术增加

本研究表明,COVID-19大流行期间,儿童胆囊切除术案例数量和复杂性均有所增加。这些发现可能与儿童健康状况的变化、转诊模式以及就医途径的转变有关,这突显了儿童医院日益增加的医疗保健负担。

Arthritis Care Res:农村地区居住的特发性免疫性或炎症性风湿病患者在COVID-19感染后的两年内死亡风险如何?

农村地区居住的特发性免疫性或炎症性风湿病患者在COVID-19感染后的两年内死亡风险较高。

Epidemiology and Psychiatric Sciences:疫情期间青少年和年轻人抗抑郁药物使用激增的时间序列分析洞察

COVID-19疫情期间,青少年和年轻人抗抑郁药物使用显著增加,特别是女性和非意大利籍青少年增幅尤为突出,提示心理健康需求可能在疫情后持续增加。

Int Forum Allergy Rhinol:嗅觉训练与年龄有关的差异

美国科学家发现,50岁以下的年轻患者和50岁以上的年长患者在接受OT治疗后,嗅觉功能都有类似的明显改善。但两组患者的主观改善时间不同,年轻患者的改善时间更早。