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FASEB J：研究发现白色脂肪向棕色脂肪转换的化学物质

2016-10-16 MedSci MedSci原创

Beta-LGND2　脂肪　肥胖　代谢综合征
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近日，据发表于FASEB J的一项新的研究表明，通过雌激素受体β（ERβ）激活一种称为Beta-LGND2的化学物质，可将“坏”脂肪（白色脂肪）转换成“好”脂肪（棕色脂肪），从而可改善小鼠肥胖和代谢疾病。棕色脂肪可增加代谢，并可能有助于减肥。研究人员设置了三组小鼠，其中一组喂食正常饮食，而其余两组给予高脂饮食（HFD）从而使小鼠肥胖。其中一组高脂喂养组小鼠使用赋形剂处理，而另一组高脂喂养组小鼠接受

近日，据发表于FASEB J的一项新的研究表明，通过雌激素受体β（ERβ）激活一种称为Beta-LGND2的化学物质，可将“坏”脂肪（白色脂肪）转换成“好”脂肪（棕色脂肪），从而可改善小鼠肥胖和代谢疾病。棕色脂肪可增加代谢，并可能有助于减肥。

研究人员设置了三组小鼠，其中一组喂食正常饮食，而其余两组给予高脂饮食（HFD）从而使小鼠肥胖。其中一组高脂喂养组小鼠使用赋形剂处理，而另一组高脂喂养组小鼠接受Beta-LGND2处理。

结果发现，与其他接受高脂饮食的小鼠相比，接受Beta-LGND2处理的小鼠明显偏瘦。Beta-LGND2组小鼠的身体温度和氧耗量较高，表明这些小鼠的代谢率较高。

代谢综合征和肥胖威胁着世界各地的数百万人的健康，此研究或为这些疾病的治疗提供一个有益的药理学治疗前景。

原始出处：

New molecule may help fight obesity by converting 'bad' fat to 'good' fat. Science Daily, October 14, 2016.

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

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    2017-04-25 hanhaisha2020

    #研究发现#

    0

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    2016-11-21 liuyg0240

    #白色脂肪#

    0

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    2017-06-11 gracezdd

    #FAS#

    0

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createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-17 深海的鱼

    转化

    0

  5. 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    2016-10-17 圣艮山

    终于显示出来了

    0

  6. 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    2016-10-16 1e1487afm65(暂无匿称)

    这是一个热点

    0

  7. 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createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 lietome1

    学习了，赞一个！

    0

  8. 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createdBy=017537082563, createdName=liuyg0240, createdTime=Mon Nov 21 16:59:00 CST 2016, time=2016-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057920, encodeId=259b205e920e9, content=<a href='/topic/show?id=3836e24819' target=_blank style='color:#2F92EE;'>#FAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7248, encryptionId=3836e24819, topicName=FAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Sun Jun 11 05:59:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148918, encodeId=40ec14891827, content=转化, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Mon Oct 17 07:14:35 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148900, encodeId=5ff1148900c0, content=终于显示出来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Mon Oct 17 06:06:32 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148884, encodeId=2289148884fa, content=这是一个热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161013/IMG57FF1AB36A79C3246.jpg, createdBy=b0911965225, createdName=1e1487afm65(暂无匿称), createdTime=Sun Oct 16 23:43:08 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148849, encodeId=0c41148849d9, content=学习了，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=841a1636000, createdName=lietome1, createdTime=Sun Oct 16 18:46:54 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148838, encodeId=d479148838a8, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0df71676643, createdName=1de2495dm19(暂无匿称), createdTime=Sun Oct 16 17:34:47 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148813, encodeId=89741488137a, content=现在这种物质很多呀，为什么这么多人关注这点, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Sun Oct 16 14:26:29 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148810, encodeId=2cab148810e9, content=好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 1de2495dm19(暂无匿称)

    继续学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1753163, encodeId=2ce31e5316338, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Tue Apr 25 03:59:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756231, encodeId=a4f81e562314f, content=<a href='/topic/show?id=1303e175932' target=_blank style='color:#2F92EE;'>#白色脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71759, encryptionId=1303e175932, topicName=白色脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=017537082563, createdName=liuyg0240, createdTime=Mon Nov 21 16:59:00 CST 2016, time=2016-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057920, encodeId=259b205e920e9, content=<a href='/topic/show?id=3836e24819' target=_blank style='color:#2F92EE;'>#FAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7248, encryptionId=3836e24819, topicName=FAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Sun Jun 11 05:59:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148918, encodeId=40ec14891827, content=转化, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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authenticateStatus=null, createdAvatar=, createdBy=0df71676643, createdName=1de2495dm19(暂无匿称), createdTime=Sun Oct 16 17:34:47 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148813, encodeId=89741488137a, content=现在这种物质很多呀，为什么这么多人关注这点, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Sun Oct 16 14:26:29 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148810, encodeId=2cab148810e9, content=好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 圣艮山

    现在这种物质很多呀，为什么这么多人关注这点

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1753163, encodeId=2ce31e5316338, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Tue Apr 25 03:59:00 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756231, encodeId=a4f81e562314f, content=<a href='/topic/show?id=1303e175932' target=_blank style='color:#2F92EE;'>#白色脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71759, encryptionId=1303e175932, topicName=白色脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=017537082563, createdName=liuyg0240, createdTime=Mon Nov 21 16:59:00 CST 2016, time=2016-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057920, encodeId=259b205e920e9, content=<a href='/topic/show?id=3836e24819' target=_blank style='color:#2F92EE;'>#FAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7248, encryptionId=3836e24819, topicName=FAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Sun Jun 11 05:59:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148918, encodeId=40ec14891827, content=转化, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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authenticateStatus=null, createdAvatar=, createdBy=0df71676643, createdName=1de2495dm19(暂无匿称), createdTime=Sun Oct 16 17:34:47 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148813, encodeId=89741488137a, content=现在这种物质很多呀，为什么这么多人关注这点, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Sun Oct 16 14:26:29 CST 2016, time=2016-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148810, encodeId=2cab148810e9, content=好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Sun Oct 16 13:24:54 CST 2016, time=2016-10-16, status=1, ipAttribution=)]
    2016-10-16 1def5ef1m18(暂无匿称)

    好！

    0

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