刘颖斌教授:胰头癌全系膜切除(TMpE)可提高R0切除率,改善预后

2019-03-28 佚名 ioncology

胰腺系膜切除是实现胰腺癌R0切除的关键,而后切缘的阴性则是决定胰腺癌预后的重要因素之一。正是基于该理念,国内外开始提出胰头癌全系膜切除(TMpE)的手术方式,相关研究亦显示TMpE可在一定程度上提高胰头癌的R0切除率、减少局部复发和改善预后。

胰腺系膜切除是实现胰腺癌R0切除的关键,而后切缘的阴性则是决定胰腺癌预后的重要因素之一。正是基于该理念,国内外开始提出胰头癌全系膜切除(TMpE)的手术方式,相关研究亦显示TMpE可在一定程度上提高胰头癌的R0切除率、减少局部复发和改善预后。

胰头癌全系膜切除术(TMpE)疗效渐获认可

胰头癌全系膜切除术(TMpE)是由我们团队率先在国内提出,并推动其应用至胰头癌的外科治疗中。由于胰腺癌的恶性程度极高,在外科手术后的复发率达到了75%~100%,其中以局部复发最为常见,而复发则严重影响了胰腺癌患者的总体生存。正是基于该情况,国内外开始提出胰头癌全系膜切除术(TMpE),旨在提高胰头癌患者的R0切除率,减少局部复发,以期达到改善预后的目标。TMpE刚开始在国内提出时引起了一定的争议,但随着TMpE的应用及相关研究的佐证,目前TMpE在胰头癌中的疗效逐渐获得了更多的认同。

胰腺全系膜切除(TMpE)针对于胰腺癌淋巴转移和神经转移的特性,对易出现转移并导致术后局部复发的重要区域进行彻底的清扫,提高根治切除率,改善生存时间。目前关于胰腺全系膜切除的争议主要集中于手术安全性和效果的评价,现在我们单中心研究的数据已经证明了胰腺全系膜切除(TMpE)具有良好的安全性和手术效果。该理念也在国内多个中心得到了良好的推广,我们将联合其他中心对胰腺全系膜切除技术(TMpE)进一步进行效果评价。

围手术期治疗重要性不容忽视

围手术期的治疗是胰腺癌治疗的重要组成部分,胰腺癌围手术期治疗我认为可以归结于两个方面:一方面是提高手术安全性方面的治疗,包括术前减黄、合并症处理、术后并发症的治疗等等;另一方面在于提高手术切除率和根治切除率。在手术安全性方面,目前围手术期治疗趋于标准化和规范化,提高了胰腺癌围手术期的安全性。另外,包括新辅助化疗等转化治疗理念的更新,使得原来认为不可手术切除的患者重新获得手术治疗的机会,大大提高了手术切除率,甚至得到根治切除,使相对晚期的胰腺癌患者得到生存获益。

微创术式在胰腺癌外科治疗中的应用前景广阔

目前,微创手术已经广泛应用至几乎所有的外科领域,胰腺癌微创治疗的技术,包括腹腔镜和达芬奇系统下的胰腺癌微创手术技术正在日益成熟,近期疗效相对于传统开腹手术具有一定的优势。腹腔镜下胰腺癌微创手术在国内只有少数中心相对领先,大多数中心尚在起步摸索阶段,因此结合远期生存数据来评价其远期疗效为时尚早,但在不远的将来,中国多中心的研究结果就会解答这个问题。

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    2019-04-29 feather89
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    2020-02-06 soongzhihua
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