J Mater Sci Mater Med:铜沉积钛表面可降低致病菌的存活率

2019-07-28 sunshine 译 MedSci原创

本研究旨在评估铜沉积钛表面对种植体周围炎相关菌株牙龈卟啉单胞菌的抗菌作用。采用沉积-阳极氧化工艺中的火花辅助阳极氧化方法将铜沉积在由钛制成的盘上。该方法允许通过改变处理时间在表面上沉积不同浓度的铜。研究牙龈卟啉单胞菌在2,4和6小时内在盘上的粘附以及研究溶液中释放的铜的抗菌作用。结果显示,铜沉积的圆盘可显著抑制细菌细胞的活力,在6小时后CFU减少3个对数单位。在6小时的孵育时间后,溶液中释放的铜导

本研究旨在评估铜沉积钛表面对种植体周围炎相关菌株牙龈卟啉单胞菌的抗菌作用。

采用沉积-阳极氧化工艺中的火花辅助阳极氧化方法将铜沉积在由钛制成的盘上。该方法允许通过改变处理时间在表面上沉积不同浓度的铜。研究牙龈卟啉单胞菌在2,4和6小时内在盘上的粘附以及研究溶液中释放的铜的抗菌作用。

结果显示,铜沉积的圆盘可显著抑制细菌细胞的活力,在6小时后CFU减少3个对数单位。在6小时的孵育时间后,溶液中释放的铜导致减少CFU减少4个对数单位。孵育时间为6小时,CFU计数随着圆盘上铜浓度的增加而降低(1.3μg/圆盘为2%;5.6μg/圆盘为32%;9.5μg/圆盘为34%)。然而,在较高铜浓度的17.7μg/圆盘下,6小时后,CFU计数的降低不如在溶液中观察到的那样明显。

总之,铜官能化钛显著降低了附着细菌的存活率并降低了钛周围环境中的活菌数。因此,植入物周围的区域受到从表面释放的铜的保护,形成用于改善种植体愈合的“安全区”。

原始出处:

Astasov-Frauenhoffer M, Koegel S, et al., Antimicrobial efficacy of copper-doped titanium surfaces for dental implants. J Mater Sci Mater Med. 2019 Jul 10;30(7):84. doi: 10.1007/s10856-019-6286-y.

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    2019-11-17 30397613
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    2019-07-30 cooco