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Am J Pathol：新型Wnt调节剂NEL样分子-1拮抗脂肪生成和增加骨形态发生蛋白2诱导的成骨作用

2019-03-23 不详 网络

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既往研究已经报道了分化因子NEL样分子-1（NELL-1）在多种体内临床前模型中具有骨诱导能力。骨形态发生蛋白（BMP）-2在临床上用于骨骼修复，但是体内施用可以诱导异常的，脂肪填充的，质量差的骨。我们证明NELL-1与BMP2联合显着优化了啮齿动物股骨节段缺损模型中的成骨作用，通过最小化BMP2诱导的脂肪填充的囊样骨的形成。使用小鼠骨髓基质细胞系M2-10B4和人原代骨髓基质细胞的体外研究已经证

既往研究已经报道了分化因子NEL样分子-1（NELL-1）在多种体内临床前模型中具有骨诱导能力。骨形态发生蛋白（BMP）-2在临床上用于骨骼修复，但是体内施用可以诱导异常的，脂肪填充的，质量差的骨。

我们证明NELL-1与BMP2联合显着优化了啮齿动物股骨节段缺损模型中的成骨作用，通过最小化BMP2诱导的脂肪填充的囊样骨的形成。使用小鼠骨髓基质细胞系M2-10B4和人原代骨髓基质细胞的体外研究已经证实NELL-1增强BMP2诱导的骨生成并抑制BMP2诱导的脂肪生成。重要的是，NELL-1将BMP2处理的细胞导向成骨并远离脂肪形成的能力需要完整的经典Wnt信号通路传导。

总体而言，这些研究确立了将NELL-1与BMP2结合以改善临床骨再生的可行性，并提供了在NELL-1和BMP2成骨过程中经典Wnt途径活性的机制洞察。NELL-1刺激Wnt信号传导和抑制脂肪生成的新能力可能突出了骨质疏松症中骨丢失的新治疗方法。

原始出处：

Jia Shen, Aaron W. James, et al., Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2. Am J Pathol. 2016 Feb; 186(2): 419–434.

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    2019-10-03 yb6560

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    2019-11-26 ms1467340776200723

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    2019-03-25 zhaojie88

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    2019-03-25 zhwj

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