EASD 2013:2型糖尿病患者一日少次多量进餐或能获益更多

2013-09-30 佚名 丁香园

2型糖尿病(T2D)治疗中热量限制是非常重要,典型的方法是(但也不一定)将一天中总热量分为5或6次少量进餐。已有证据表明等热量的大量混合餐比相同食物分为6小份消耗导致更多的餐后产热效应。为了比较2型糖尿病患者在相同热量限制下,一天6次进餐与一天两次进餐对体重、HbA1c和静息能量消耗的影响,来自捷克布拉格内分泌研究所的Hana Kahleova教授及其团队进行了一项研究,该研究发现2型糖尿病患

2型糖尿病(T2D)治疗中热量限制是非常重要,典型的方法是(但也不一定)将一天中总热量分为5或6次少量进餐。已有证据表明等热量的大量混合餐比相同食物分为6小份消耗导致更多的餐后产热效应。为了比较2型糖尿病患者在相同热量限制下,一天6次进餐与一天两次进餐对体重、HbA1c和静息能量消耗的影响,来自捷克布拉格内分泌研究所的Hana Kahleova教授及其团队进行了一项研究,该研究发现2型糖尿病患者一天两次进餐与相同热量限制食物分成6次以上进餐相比,体重、空腹血糖和血浆C肽下降更多。该研究结果在线发表在2013年EASD会议上。

该研究在一项随机交叉研究中,将54例2型糖尿病患者分到两种低热量饮食方案,每种方案12周:一天6次进餐(A)和一天2次进餐(B)。两种方案的食物有相同的常量营养元素和能量。在0、12和24周测量受试者体重、HbA1c,并使用代谢监测仪VMAX进行间接测热量测定。预测静息能量消耗(REE)依据Harris–Benedict方程计算。使用2×2交叉ANOVA进行统计分析。

该研究结果表明,两种方案的体重都下降,B方案体重下降更多。两种方案的空腹C肽都下降,B方案空腹C肽下降更多。两种方案的HbA1c都下降,B方案HbA1c倾向于下降更多,但两种方案的差别没有统计学意义。两种方案的血浆免疫反应性胰岛素、甘油三酯和LDL胆固醇有同等程度的下降。两种方案的呼吸商都增加,A方案倾向于增加更多。两种方案的REE测量值都下降,A方案倾向于有更大幅度的下降。假如依据Harris–Benedict方程计算预测REE百分比,两种方案REE都下降,A方案倾向于有下降更多。

该研究发现,2型糖尿病患者一天两次进餐与相同热量限制食物分成6次以上进餐相比,体重、空腹血糖和血浆C肽下降更多。提示2型糖尿病患者一天中少次多量进餐可能比少量多次进餐更好。

 

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    2014-01-15 okhuali

    #ASD#

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    2013-10-02 aids213
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    2013-10-02 xue8604
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    2013-10-02 qilu_qi

    #EASD#

    0

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