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J Biomed Mater Res A：负载大豆黄素的PHBV微球的45S5生物活性玻璃基支架的制备和表征

2018-01-23 MedSci MedSci原创

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本研究中，研究人员开发了聚（3-羟基丁酸酯-共-3-羟基戊酸酯）（PHBV）微球装载具有药物释放能力的45S5生物活性玻璃（BG）基支架。通过水包油单溶剂蒸发法得到平均粒径为4±2μm的负载大豆黄素的PHBV微球，并通过浸涂技术将其涂布在BG支架表面。此外，研究人员还探究了模拟体液（SBF）的形态，体外生物活性，力学性能和载药微球载药量的释放动力学。结果显示，微球均匀地分散在支架表面上。而且羟基磷

本研究中，研究人员开发了聚（3-羟基丁酸酯-共-3-羟基戊酸酯）（PHBV）微球装载具有药物释放能力的45S5生物活性玻璃（BG）基支架。

通过水包油单溶剂蒸发法得到平均粒径为4±2μm的负载大豆黄素的PHBV微球，并通过浸涂技术将其涂布在BG支架表面。此外，研究人员还探究了模拟体液（SBF）的形态，体外生物活性，力学性能和载药微球载药量的释放动力学。

结果显示，微球均匀地分散在支架表面上。而且羟基磷灰石晶体不仅在支架表面均匀生长，而且在SBF浸泡后3天内均匀生长在微球表面。大豆黄素从微球支架释放持续近1个月，且为控释。

综上所述，该研究结果表明，本研究所制备的具有大豆黄素释放能力的微球装载的BG支架可作为骨组织工程的候选材料之一。

原始出处：

Macías-Andrés VI, Li W, et al., Preparation and characterization of 45S5 bioactive glass-based scaffolds loaded with PHBV microspheres with daidzein release function. J Biomed Mater Res A. 2017 Jun;105(6):1765-1774. doi: 10.1002/jbm.a.36046. Epub 2017 Apr 3.

评论区 (6)
#插入话题
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    2018-12-01 klivis

    #HBV#

    0

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    2018-06-14 fyxzlh

    #生物活性玻璃#

    0

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    2018-07-10 sunylz

    #Bio#

    0

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    2018-01-25 ms3994565386320060

    #Med#

    0

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    2018-01-23 131****1460

    学习了受益匪浅

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1836648, encodeId=a676183664860, content=<a href='/topic/show?id=f9d08524be' target=_blank style='color:#2F92EE;'>#HBV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8524, encryptionId=f9d08524be, topicName=HBV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Sat Dec 01 17:08:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005175, encodeId=670d20051e51f, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Thu Jun 14 15:08:00 CST 2018, time=2018-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917894, encodeId=6fc5191e8945f, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jul 10 14:08:00 CST 2018, time=2018-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608470, encodeId=196316084e0e8, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Jan 25 09:08:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281315, encodeId=7aaa281315aa, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue Jan 23 19:44:59 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281284, encodeId=aa21281284b0, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Jan 23 19:03:57 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 惠映实验室

    学习了.谢谢分享.

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