肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

NEJM：BCMA靶向CAR-T细胞疗法Idecabtagene Vicleucel（Ide-cel）取得积极结果

2021-02-25 Allan MedSci原创

Car-T细胞疗法BCMAidecabtagene vicleucel
关注

II期KarMMa试验评估了bluebird bio和Bristol Myers Squibb的B细胞成熟抗原（BCMA）靶向的CAR-T细胞疗法的功效和安全性。

II期KarMMa试验评估了bluebird bio和Bristol Myers Squibb的B细胞成熟抗原（BCMA）靶向的CAR-T细胞疗法的功效和安全性。idecabtagene vicleucel（ide-cel，bb2121）旨在治疗复发难治多发性骨髓瘤（RRMM），这些患者先前已经接受过至少三种疗法，包括免疫调节剂、蛋白酶体抑制剂和抗CD38抗体。这项研究今天发表在《新英格兰医学杂志》上。

KarMMa研究达到了总体缓解率的主要终点和完全缓解率的关键次要终点。数据表明，三重暴露的RRMM患者（n = 128）接受ide-cel治疗可产生深度且持久的反应。

在所有剂量水平和多个高危亚组中，包括大量高危细胞遗传学、三重或五重难治性疾病、基线时肿瘤高负荷和髓外疾病的患者，均报告了有临床意义的反应。患者的中位无进展生存期和总生存期也得到了显著改善。

在KarMMa研究中，ide-cel与CAR-T细胞疗法的已知毒性一致，而与剂量水平无关。最常报告的不良事件是血细胞减少和细胞因子释放综合征。

 

原始出处：

https://www.firstwordpharma.com/node/1803935?tsid=4

评论区 (10)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-11-30 cy0324

    #Gene#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2022-02-04 12498ef1m41(暂无昵称)

    #idecabtagene vicleucel#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-11-23 维他命

    #CEL#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-11-16 仁者大医

    #CAR-#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-02-28 黄昏晓Time

    免疫疗法进展迅速#免疫疗法#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-02-27 changjitao2009

    #Car-T细胞疗法#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-02-27 yykkxiaodou

    #BCMA#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-02-27 124984edm24暂无昵称

    #T细胞疗法#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-02-25 旺医

    顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2049371, encodeId=a01320493e1eb, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 30 17:12:28 CST 2021, time=2021-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715512, encodeId=38f91e15512d6, content=<a href='/topic/show?id=9c959406fa' target=_blank style='color:#2F92EE;'>#idecabtagene vicleucel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9406, encryptionId=9c959406fa, topicName=idecabtagene vicleucel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=753b31938391, createdName=12498ef1m41(暂无昵称), createdTime=Fri Feb 04 23:12:28 CST 2022, time=2022-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962464, encodeId=8f0e1962464b8, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Nov 23 05:12:28 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781418, encodeId=41111e814184d, content=<a href='/topic/show?id=8ce8405907' target=_blank style='color:#2F92EE;'>#CAR-#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4059, encryptionId=8ce8405907, topicName=CAR-)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Nov 16 20:12:28 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944154, encodeId=71a89441548b, content=免疫疗法进展迅速<a href='/topic/show?id=e6dd29094a1' target=_blank style='color:#2F92EE;'>#免疫疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29094, encryptionId=e6dd29094a1, topicName=免疫疗法)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Sun Feb 28 12:21:45 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291575, encodeId=125d12915e523, content=<a href='/topic/show?id=2acd40e7ba' target=_blank style='color:#2F92EE;'>#Car-T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4077, encryptionId=2acd40e7ba, topicName=Car-T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db7c233, createdName=changjitao2009, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460233, encodeId=636c14602338d, content=<a href='/topic/show?id=833732e80d' target=_blank style='color:#2F92EE;'>#BCMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3278, encryptionId=833732e80d, topicName=BCMA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85f46265562, createdName=yykkxiaodou, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478056, encodeId=b64114e80569d, content=<a href='/topic/show?id=bb6f18030a4' target=_blank style='color:#2F92EE;'>#T细胞疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18030, encryptionId=bb6f18030a4, topicName=T细胞疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bea7392214, createdName=124984edm24暂无昵称, createdTime=Sat Feb 27 11:12:28 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035587, encodeId=71ac103558ea4, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Feb 25 23:12:28 CST 2021, time=2021-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=927224, encodeId=ff5292e2249e, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Thu Feb 25 21:20:44 CST 2021, time=2021-02-25, status=1, ipAttribution=)]
    2021-02-25 ms2000001051330459

    学习了，涨知识了！

    0

以上为热门评论，梅斯医学App还有更多内容

相关资讯

FDA批准CAR-T细胞疗法Tecartus治疗复发难治套细胞淋巴瘤

Tecartus是第一个获批用于治疗MCL的CAR-T细胞疗法。

Lenzilumab预防或治疗与CAR-T细胞疗法相关细胞因子风暴和神经毒性

临床阶段生物制药公司Humanigen今天宣布，美国专利商标局已向公司授予一项专利，该专利用于使用lenzilumab预防或治疗接受嵌合抗原受体T（CAR-T）细胞治疗的患者的细胞因子风暴和神经毒性。

**iPSC衍生的CAR-T细胞疗法：IND已获FDA批准

Fate Therapeutics是一家临床阶段的生物制药公司，致力于开发抗癌症和免疫疾病的细胞免疫疗法，今日宣布，美国FDA已批准FT819的研究性新药申请（IND）。

CAR-T细胞免疫疗法临床研究与伦理审查实践

CAR-T细胞免疫疗法仍属于新兴技术，在目前开展的临床研究中，其技术标准、临床疗效与潜在风险尚需长期更多数据的积累。如何合理开展临床研究，使患者尽快安全、有效地获益于CAR-T细胞免疫疗法，仍需不断探

CAR-T细胞疗法Idecabtagene Vicleucel治疗复发难治多发性骨髓瘤：已提交BLA

idecabtagene vicleucel（ide-cel，bb2121）是一款研究性靶向B细胞成熟抗原（BCMA）的嵌合抗原受体（CAR）T细胞免疫疗法，用于治疗复发难治性多发性骨髓瘤。

CRISPR编辑的CAR-T细胞疗法增强了对抗血癌的能力

宾夕法尼亚大学医学院研究人员的最新临床前数据显示，使用CRISPR / Cas9技术敲除一种已知可抑制T细胞活化的蛋白，从而增强了工程T细胞消除血液癌的能力。

拓展阅读

【CBM】钱文斌/张会来教授等总结提高CAR-T淋巴瘤疗效的策略

本文综述了近年来为提高CAR-T细胞疗法在淋巴瘤治疗中的疗效所采取的多项策略，包括改进抗原识别、抑制免疫检查点信号、增强杀伤能力、提高安全性以及代谢和表观遗传调控等方面的创新方法。

综述：CAR-T的神经毒性

CAR-T 细胞疗法治疗癌症有疗效但伴神经毒性，综述探讨 ICANS、MNT、TIAN 三类神经毒性，分析其临床特征、机制、诊断等，强调多学科协作重要性。

首次报道！CART治疗DLBCL后五年持续存在CART细胞，成功自然怀孕并妊娠

近日报道了一例女性病例，该患者有弥漫性大 B 细胞淋巴瘤（DLBCL）病史，接受试验性 CAR-T 细胞治疗，5年后仍持续存在 CAR-T 细胞，随后妊娠并产下一名健康男孩。

【Nature子刊】CAR-T治疗DLBCL失败后格菲妥单抗治疗，中位OS达14.7个月：一项2期研究结果

针对 CAR - T 治疗失败的 DLBCL 患者，LYSA 开展前瞻性 2 期研究。结果显示，格菲妥单抗抗肿瘤活性显著，安全性良好，可作为新的治疗选择。

【AJH】创新治疗：环磷酰胺成功治疗CD19 CAR-T引起的致命ICANS

安徽医科大学附院报告，一 50 岁 ALL 女性用 CD19 CAR-T 治疗后出现致命 ICANS，使用环磷酰胺成功救治，为 CAR-T 治疗中 ICANS 的处理提供新思路。

从血液到实体瘤：CAR-T疗法的“中国方案”与全球突破

中国 CAR - T 疗法在肿瘤治疗领域成果斐然，血液恶性肿瘤已有五款产品获批。实体瘤探索也有进展，多个瘤种临床试验显示疗效，还挖掘出 Claudin18.2 等潜力靶点，前景广阔但面临挑战。