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Lancet haemat：Q热或与非霍奇金淋巴瘤的发病率无相关性

2018-04-10 MedSci MedSci原创

Q热非霍奇金淋巴瘤
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有人提出伯纳特氏立克次氏体（Coxiella burnetii）与非霍奇金淋巴瘤存在相关性。2007年-2010年，荷兰出现一次大规模的Q热流行病之后，Sonja E van Roeden等人猜想在Q热高发地区，在低流行地区相比，非霍奇金淋巴瘤的发病率是否会增加，并推测进行探究。研究人员进行一回顾性人群为基础的分析，估算Q热中高流行地区在Q热流行前1年、流行期和流行后非霍奇金淋巴瘤的相对风险（RR

有人提出伯纳特氏立克次氏体（Coxiella burnetii）与非霍奇金淋巴瘤存在相关性。2007年-2010年，荷兰出现一次大规模的Q热流行病之后，Sonja E van Roeden等人猜想在Q热高发地区，在低流行地区相比，非霍奇金淋巴瘤的发病率是否会增加，并推测进行探究。

研究人员进行一回顾性人群为基础的分析，估算Q热中高流行地区在Q热流行前1年、流行期和流行后非霍奇金淋巴瘤的相对风险（RRs）。同时估算非霍奇金淋巴瘤在慢性Q热患者中的RR。

2002年1月1日-2013年12月31日，共诊断48760例非霍奇金淋巴瘤。非霍奇金淋巴瘤的发病率，2002年为21.4/100 000人年，2010年为26.7/100 000人年。2009年，与Q热低流行区相比，Q热高发区与非霍奇金淋巴瘤存在明显的相关性（RR 1.16，95% CI 1.02-1.33；P=0.029）；但在其他年份未观察到关联。439位慢性Q热患者，有5位罹患非霍奇金淋巴瘤，与荷兰的正常人群相比的绝对风险为301.0/100 000人年(RR 4.99，95%CI 2.07-11.98；p=0.0003）。

本研究结果不支持Q热在非霍奇金淋巴瘤的发病中存在因果关系。但也可能是本研究固有的局限性导致研究结果存在偏差。

原始出处：

Sonja E van Roeden，et al. Exposure to Coxiella burnetii and risk of non-Hodgkin lymphoma： a retrospective population-based analysis in the Netherlands.The Lancet Haematology. April 09，2018.https：//doi.org/10.1016/S2352-3026(18)30038-3

本文系梅斯医学（MedSci）原创编译，转载需授权！

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    2018-06-02 howi

    #Lancet#

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    2019-01-07 医者仁心

    #发病率#

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    2019-02-24 shenxlcyp

    #相关性#

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    2018-04-17 changfy

    #HAE#

    0

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    2018-04-16 semrour

    顶!用事实证明猜想

    0

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    2018-04-12 fengyi812

    #EMA#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1829583, encodeId=a2d11829583be, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Jun 02 14:20:00 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823451, encodeId=6da41823451e9, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Jan 07 06:20:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837489, encodeId=c427183e4899e, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sun Feb 24 11:20:00 CST 2019, time=2019-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008358, encodeId=90a52008358bb, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Tue Apr 17 19:20:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306309, encodeId=fc4230630928, content=顶!用事实证明猜想, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cabb1969833, createdName=semrour, createdTime=Mon Apr 16 09:47:11 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1317392, encodeId=4137131e392a1, content=<a href='/topic/show?id=74916e0414' target=_blank style='color:#2F92EE;'>#EMA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6704, encryptionId=74916e0414, topicName=EMA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Thu Apr 12 02:20:00 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304475, encodeId=21313044e56d, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Tue Apr 10 11:41:31 CST 2018, time=2018-04-10, status=1, ipAttribution=)]
    2018-04-10 神功盖世

    阅

    0