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Sci Rep：TRPM7和MagT1在体外对人间充质干细胞成骨分化的影响

2018-11-12 MedSci MedSci原创

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间充质干细胞是骨形成和修复的基础，因为它们通过经历成骨分化来响应微环境刺激。 本研究结果显示，激酶和阳离子通道TRPM7和镁转运蛋白MagT1在协调人间充质干细胞的成骨分化中起作用。TRPM7和MagT1在成骨分化和沉默中上调，其中任一个加速成骨分化，部分通过自噬的激活。有趣的是，当细胞在缺镁条件下培养时，获得了类似的结果。 综上所述，这些结果支持镁，TRPM7和MagT1对自噬和

间充质干细胞是骨形成和修复的基础，因为它们通过经历成骨分化来响应微环境刺激。

本研究结果显示，激酶和阳离子通道TRPM7和镁转运蛋白MagT1在协调人间充质干细胞的成骨分化中起作用。TRPM7和MagT1在成骨分化和沉默中上调，其中任一个加速成骨分化，部分通过自噬的激活。有趣的是，当细胞在缺镁条件下培养时，获得了类似的结果。

综上所述，这些结果支持镁，TRPM7和MagT1对自噬和成骨细胞生成的作用。

原始出处：

Sara Castiglioni, Valentina Romeo, et al., TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro. Sci Rep. 2018; 8: 16195.

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    2018-11-26 HinsMax

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