Breast:保乳手术中切缘那些事儿

2017-07-26 王强 肿瘤资讯

乳腺肿瘤保乳手术后局部复发的有关因素很多,其中最重要的是切除标本镜下切缘情况。目前对浸润性乳腺癌或导管原位癌保乳术后切缘阴性及恰当距离的准确定义尚无共识。

乳腺肿瘤保乳手术后局部复发的有关因素很多,其中最重要的是切除标本镜下切缘情况。目前对浸润性乳腺癌或导管原位癌保乳术后切缘阴性及恰当距离的准确定义尚无共识。随着人民群众健康意识的提高、以及乳腺相关检查手段和治疗方案的进步,早期浸润性乳腺癌及原位癌检出越来越多,保乳手术也越来越多。当然,某些病例保乳、甚至单纯乳腺切除术后会出现局部复发。与局部复发有关的因素有很多,如患者自身因素、治疗方面的因素、病理学因素等,毫无疑问,这其中最重要的是切除标本镜下切缘情况。本文即对浸润性乳腺癌或原位癌保乳术后切缘相关的部分问题进行简介。由于患有浸润性乳腺癌及导管原位癌时,患者均有肿物切除术后再行二次手术的情况,甚至某些切缘已经阴性、但认为切缘宽度不足的患者也是如此。鉴于二次手术会带来焦虑、并发症、美容效果差、费用以及延迟全面治疗等一系列问题,因此恰当的定义切缘阴性及距离,从而减少不必要的二次手术成了一个重要的临床目标。浸润性癌的切缘问题以往浸润性乳腺癌或导管原位癌保乳术后切缘阴性及恰当距离的准确定义尚无共识,且随机临床试验中也从未强调这一点。随着当下系统治疗的进步、对肿瘤生物学行为了解的深入,目前已逐渐认识

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    2017-11-28 zhouqu_8
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    2017-07-28 zhaojie88