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Circulation:ENGAGE AF-TIMI 48:依度沙班用于预防心房纤颤和生物假体瓣膜患者的血栓栓塞

2017-02-22 MedSci MedSci原创

ENGAGEAF-TIMI48心房纤颤生物假体瓣膜依度沙班
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试验ENGAGE AF-TIMI 48，在房颤患者中 将依度沙班（一种直接口服的凝血因子抑制剂）与华法林进行比较，并且不排除生物假体瓣膜患者，从而为分析该高危亚组提供了机会。

心房颤动和瓣膜性心脏病经常共存，并可独立增加死亡率。人工瓣膜植入（手术或经导管）越来越多的用于瓣膜性心脏病的治疗。房颤和生物假体瓣膜患者需要抗凝治疗以预防血栓栓塞事件。

口服非维生素K抗凝剂（NOACs）是房颤抗凝治疗中维生素K拮抗剂的安全有效的替代物。然而，指南推荐尚缺乏数据支持对生物假体瓣膜患者应用NOACs。在房颤患者中 以华法林作为对照的三个关键性NOAC试验中，仅有一个包括生物假体瓣膜患者（n> 80）。

一项名为在心肌梗死在房颤溶栓中的下一代因子Xa的有效抗凝作用48（ENGAGE AF-TIMI 48）试验中，在房颤患者中将依度沙班（一种直接口服的凝血因子抑制剂）与华法林进行比较，并且不排除生物假体瓣膜患者，从而为分析该高危亚组提供了机会。

此外，这项名为ENGAGE AF-TIMI 48的实验尚有其余5篇文章发表在Pubmed：该项试验第一篇文章《心房纤颤患者中依度沙班vs华法林》于2013年11月发表在新英格兰医学杂志，另外还包括关于脑血管事件、心脏复律的分析研究。

原始出处：

Carnicelli AP， De Caterina R， Halperin JL，et al；Edoxaban for the Prevention of Thromboembolism in Patients with AtrialFibrillation and Bioprosthetic Valves.Circulation. 2017 Feb 16. pii： CIRCULATIONAHA.116.026714.

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

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    2017-03-02 gracezdd

    #AF-TIMI#

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    2017-09-29 kcb069

    #生物假体瓣膜#

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    2017-07-01 july_975

    #心房纤颤#

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    2017-03-01 spoonycyy

    #Eng#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1779390, encodeId=65651e7939071, content=<a href='/topic/show?id=34df206144' target=_blank style='color:#2F92EE;'>#AF-TIMI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2061, encryptionId=34df206144, topicName=AF-TIMI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Thu Mar 02 01:00:00 CST 2017, time=2017-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798474, encodeId=e7781e9847417, content=<a href='/topic/show?id=a8cb69205c5' target=_blank style='color:#2F92EE;'>#生物假体瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69205, encryptionId=a8cb69205c5, topicName=生物假体瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Sep 29 16:00:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033075, encodeId=aa9f20330e56f, content=<a href='/topic/show?id=d89551026d1' target=_blank style='color:#2F92EE;'>#心房纤颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51026, encryptionId=d89551026d1, topicName=心房纤颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Sat Jul 01 10:00:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081337, encodeId=b314208133e3e, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Mar 01 20:00:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468316, encodeId=5f341468316ea, content=<a href='/topic/show?id=2d3d2e5176a' target=_blank style='color:#2F92EE;'>#假体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27517, encryptionId=2d3d2e5176a, topicName=假体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b576903125, createdName=lanyan20020088, createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583495, encodeId=ef73158349574, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626830, encodeId=e5f31626830d0, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=)]
    2017-02-23 lanyan20020088

    #假体#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1779390, encodeId=65651e7939071, content=<a href='/topic/show?id=34df206144' target=_blank style='color:#2F92EE;'>#AF-TIMI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2061, encryptionId=34df206144, topicName=AF-TIMI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Thu Mar 02 01:00:00 CST 2017, time=2017-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798474, encodeId=e7781e9847417, content=<a href='/topic/show?id=a8cb69205c5' target=_blank style='color:#2F92EE;'>#生物假体瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69205, encryptionId=a8cb69205c5, topicName=生物假体瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Sep 29 16:00:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033075, encodeId=aa9f20330e56f, content=<a href='/topic/show?id=d89551026d1' target=_blank style='color:#2F92EE;'>#心房纤颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51026, encryptionId=d89551026d1, topicName=心房纤颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Sat Jul 01 10:00:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081337, encodeId=b314208133e3e, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Mar 01 20:00:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468316, encodeId=5f341468316ea, content=<a href='/topic/show?id=2d3d2e5176a' target=_blank style='color:#2F92EE;'>#假体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27517, encryptionId=2d3d2e5176a, topicName=假体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b576903125, createdName=lanyan20020088, createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583495, encodeId=ef73158349574, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626830, encodeId=e5f31626830d0, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=)]
    2017-02-23 12498e5fm17(暂无昵称)

    #瓣膜#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1779390, encodeId=65651e7939071, content=<a href='/topic/show?id=34df206144' target=_blank style='color:#2F92EE;'>#AF-TIMI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2061, encryptionId=34df206144, topicName=AF-TIMI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Thu Mar 02 01:00:00 CST 2017, time=2017-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798474, encodeId=e7781e9847417, content=<a href='/topic/show?id=a8cb69205c5' target=_blank style='color:#2F92EE;'>#生物假体瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69205, encryptionId=a8cb69205c5, topicName=生物假体瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Sep 29 16:00:00 CST 2017, time=2017-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033075, encodeId=aa9f20330e56f, content=<a href='/topic/show?id=d89551026d1' target=_blank style='color:#2F92EE;'>#心房纤颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51026, encryptionId=d89551026d1, topicName=心房纤颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Sat Jul 01 10:00:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081337, encodeId=b314208133e3e, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Mar 01 20:00:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468316, encodeId=5f341468316ea, content=<a href='/topic/show?id=2d3d2e5176a' target=_blank style='color:#2F92EE;'>#假体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27517, encryptionId=2d3d2e5176a, topicName=假体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b576903125, createdName=lanyan20020088, createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583495, encodeId=ef73158349574, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626830, encodeId=e5f31626830d0, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Thu Feb 23 18:00:00 CST 2017, time=2017-02-23, status=1, ipAttribution=)]
    2017-02-23 sodoo

    #心房#

    0