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Theranostics：石墨烯基因载体或可有效治疗胰腺癌

2017-11-30 MedSci MedSci原创

关注

自2004年成功地从石墨中剥离石墨烯以来，石墨烯和氧化石墨烯（GO）被认为是物理和化学特性最有前途的二维纳米材料，在许多领域受到了广泛的关注。GO以其独特的理化性质而著称，与碳纳米管相比，细胞毒性较小。但是到目前为止，GO在胰腺癌治疗中进行基因治疗方面的应用十分有限。在这项研究中，我们利用多功能膜GO作为基因递送系统，来高效载送HDAC1和K-ras基因的siRNA（小干扰RNA分别靶向g12c

自2004年成功地从石墨中剥离石墨烯以来，石墨烯和氧化石墨烯（GO）被认为是物理和化学特性最有前途的二维纳米材料，在许多领域受到了广泛的关注。GO以其独特的理化性质而著称，与碳纳米管相比，细胞毒性较小。但是到目前为止，GO在胰腺癌治疗中进行基因治疗方面的应用十分有限。

在这项研究中，我们利用多功能膜GO作为基因递送系统，来高效载送HDAC1和K-ras基因的siRNA（小干扰RNA分别靶向g12c HDAC1基因和K-ras基因突变）以靶向MIA PaCa-2胰腺癌细胞。双基因沉默效应的系统机理的阐明表明HDAC1和K-ras基因失活，从而导致细胞凋亡，而处理MIA PaCa-2细胞则会抑制细胞增殖和细胞周期停滞。基因沉默与NIR光热疗联合作用具有显著的抗癌作用，抑制体内肿瘤体积生长（＞80%）。此外，GO可以在一个合理的时间内在小鼠体内代谢，没有明显的副作用。

综上所述，本研究首次在体内初步应用表明，功能化GO作为胰腺癌治疗的低毒基因载体，具有广阔的应用前景。

原始出处：

Yin F, Hu K, et al., SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer. Theranostics. 2017 Feb 27;7(5):1133-1148. doi: 10.7150/thno.17841. eCollection 2017.

评论区 (6)
#插入话题
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    2018-06-14 yangjxjc

    #石墨烯#

    0

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    2018-09-30 124988c7m106暂无昵称

    #ERA#

    0

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    2017-12-07 海豹

    #Theranos#

    0

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    2018-04-20 mei539

    #载体#

    0

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    2017-12-02 docwu2019

    #有效治疗#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1651531, encodeId=85f3165153191, content=<a href='/topic/show?id=6e78e32573c' target=_blank style='color:#2F92EE;'>#石墨烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73257, encryptionId=6e78e32573c, topicName=石墨烯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db924213398, createdName=yangjxjc, createdTime=Thu Jun 14 18:44:00 CST 2018, time=2018-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738857, encodeId=cb3e1e388578f, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sun Sep 30 15:44:00 CST 2018, time=2018-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2049891, encodeId=1ba12049891db, content=<a href='/topic/show?id=852b1e3838b' target=_blank style='color:#2F92EE;'>#Theranos#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17383, encryptionId=852b1e3838b, topicName=Theranos)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3289320, createdName=海豹, createdTime=Thu Dec 07 17:44:00 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645445, encodeId=ea271645445bd, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Fri Apr 20 22:44:00 CST 2018, time=2018-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619499, encodeId=f9b316194995f, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Dec 02 14:44:00 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265811, encodeId=83302658113c, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri Dec 01 00:15:28 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-01 飛歌

    学习了很有用不错

    0