Hypertension:人群健康血管老化的患病率、相关性及预后分析!

2017-05-31 xing.T MedSci原创

虽然HVA在接受西方生活方式的个人中是可以实现的,但超过70岁的个人维持血管正常功能是具有挑战性的。虽然该研究为观察性的数据,其研究结果支持将预防策略靶向可改变的因素和行为以及肥胖,特别是防止或延缓血管衰老以及相关CVD风险。

高血压和增加的血管硬化是老化不可避免的一个部分。近日,心血管权威杂志Hypertension上发表了一篇研究文章,为了明确年龄相关的血管功能减少是否可以避免,研究人员在3196名≥50岁的Framingham研究参与者中评估了健康血管老化(HVA)的患病率、相关性和预后情况。

研究人员定义的HVA为无高血压并且脉搏波速度小于7.6米/秒(参考样本的年龄小于30岁)。总体而言,566名(17.7%)受试者存在HVA,其患病从50岁至59岁人群的30.3%下降至超过70岁人群的1%。在调整了体力活动、热量摄入和传统的心血管疾病(CVD)危险因素的回归模型中,研究人员观察发现低年龄、女性、低体重指数、使用降脂药物和没有糖尿病与HVA之间存在横断面相关性(所有P<0.001)。此外,心血管健康评分(Life’s Simple 7)每增加一个单位经年龄和性别调整后的HVA比率增加1.55倍(95%可信区间为1.38-1.74)。

在9.6年的随访期间,共有发生了391次CVD事件。在调整了包括血压的传统心血管疾病危险因素的Cox回归模型中,相比无HVA的参与者,HVA参与者发生CVD的风险比为0.45(95%可信区间为0.26-0.77)。

虽然HVA在接受西方生活方式的个人中是可以实现的,但超过70岁的个人维持血管正常功能是具有挑战性的。虽然该研究为观察性的数据,其研究结果支持将预防策略靶向可改变的因素和行为以及肥胖,特别是防止或延缓血管衰老以及相关CVD风险。

原始出处:

Teemu J. Niiranen,et al. Prevalence, Correlates, and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort The Framingham Heart Study.Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.117.09026

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2018-01-07 feather89
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    2017-06-01 tanxingdoctor

    学习啦谢谢分享

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