ANN SURG:前列腺素E1对胃肠手术患者的影响

2018-03-27 MedSci MedSci原创

前列腺素E1(PGE1)可以增加内脏血供,被认为可以降低术后胃肠道并发症发生率。ANN SURG近期发表了一篇文章,研究PGE1对因胃肠道损伤、穿孔或梗阻接受手术的患者的影响。

前列腺素E1(PGE1)可以增加内脏血供,被认为可以降低术后胃肠道并发症发生率。ANN SURG近期发表了一篇文章,研究PGE1对因胃肠道损伤、穿孔或梗阻接受手术的患者的影响。

作者回顾性分析了889例接受胃肠手术患者的信息。在所有患者中评估包括胃肠功能恢复,术后并发症和住院时间长度等临床结果。在278对匹配患者中,比较营养,免疫和炎症等变量。配对后两组间基线相似。PGE1与促进术后胃肠功能恢复有关,包括第一次肠蠕动以及术后第一次进食时间。接受PGE1治疗的患者中总术后并发症发生率(包括感染性并发症和主要并发症)降低。此外,PGE1治疗组免疫学和炎症指标C反应蛋白在术后3天降低。

文章最后认为,PGE1与临床获益有关,如促进术后胃肠功能恢复及降低急诊胃肠手术总术后并发症发生率,其原因可能与降低炎症反应有关。

原始出处:
Hao Fabao,Guo Hongjie,et al.Effects of Prostaglandin E1 on Patients Undergoing Major Gastrointestinal Surgery.ANN SURG.April 2018 doi:10.1097/SLA.0000000000002152

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2018-03-27 海之蓝

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    2018-03-27 明月清辉

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