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Heart：高灵敏度肌钙蛋白I与心血管疾病风险！

2017-10-28 xing.T MedSci原创

Hs-cTnI心血管疾病风险
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由此可见，用高灵敏度的方法测定的心肌肌钙蛋白I是致死性和非致死性心血管事件的独立预测因子，这可能有助于鉴别一般人群中的高危个体。

高敏肌钙蛋白I(Hs-cTnI)是心血管风险的新兴生物标志物。近日，在心脏病领域权威杂志Heart上发表了一篇研究文章，研究人员在一个澳大利亚人群为基础的队列中评估了Hs-cTnI作为死亡和心血管结局的预测因子的效能，并评估了是否存在性别差异。

研究人员测量了巴瑟尔顿健康研究队列中受试者（n=3939）血清中的超敏肌钙蛋白水平。结局指标为总死亡率和心血管死亡率、心血管疾病（CVD）和冠心病（CHD）事件、心力衰竭和卒中。

在66.1%的受试者（男性81.8%，女性54.4%）中可以检测到基础的Hs-cTnI（>1.2 ng/L）水平。在20年的随访中，有886人死亡（包括361名死于CVD的患者）和940名心血管病患者。调整Framingham风险评分变量，基础Hs-cTnI水平加倍时，Hs-cTnI是总死亡率（风险比（95%可信区间）为1.16（1.09至1.24）、心血管疾病的死亡率（1.33，1.23-1.44）、心血管事件（1.18，1.11-1.25）、冠心病事件（1.11，1.03-1.20）、心力衰竭（1.44，1.31-1.58）和卒中（1.13，1.03-1.24）的显著预测因子。除冠心病事件外，基础无心血管病患者（n=3215）的风险比仍然显著。性别和作为预后预测因子的Hs-cTnI之间没有显著的交互作用。与Hs-cTnI≤1.2ng/L的个体相比，Hs-cTnI≥6ng/L的男性和Hs-cTnI≥4ng/L的女性发生任何心血管事件的风险比分别为2.18（1.42-3.37）和1.84（1.30-2.62），在无CVD的亚群中仍然有意义。

由此可见，用高灵敏度的方法测定的心肌肌钙蛋白I是致死性和非致死性心血管事件的独立预测因子，这可能有助于鉴别一般人群中的高危个体。

原始出处：

Kun Zhu,et al. High-sensitivity cardiac troponin I and risk of cardiovascular disease in an Australian population-based cohort. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-312093

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

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    2018-04-08 respect

    #灵敏度#

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    2017-10-30 zhaojie88

    #ART#

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    2017-10-30 花花1368

    #疾病风险#

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    2017-10-30 andy2090

    #血管疾病#

    0

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    2017-10-30 slcumt

    #HEART#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1775917, encodeId=11131e7591760, content=<a href='/topic/show?id=ede06694367' target=_blank style='color:#2F92EE;'>#灵敏度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66943, encryptionId=ede06694367, topicName=灵敏度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd6838842412, createdName=respect, createdTime=Sun Apr 08 08:03:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356553, encodeId=57b11356553d9, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Oct 30 01:03:00 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473079, encodeId=2ff714e307924, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Mon Oct 30 01:03:00 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498312, encodeId=9f1f14983129a, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Oct 30 01:03:00 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562729, encodeId=2e041562e29e1, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Oct 30 01:03:00 CST 2017, time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576041, encodeId=c55415e60410d, content=<a href='/topic/show?id=10f7810863d' target=_blank style='color:#2F92EE;'>#肌钙蛋白I#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81086, encryptionId=10f7810863d, topicName=肌钙蛋白I)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Oct 30 01:03:00 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
    2017-10-30 heli0118

    #肌钙蛋白I#

    0