Kidney Int:心内膜炎相关GN表现研究有更新

2015-02-03 杜卉编译 中国医学论坛报

美国学者研究发现,心内膜炎相关肾小球肾炎(GN)最常见的表现为急性肾损伤(AKI),且并发金黄色葡萄球菌三尖瓣感染。论文1月21日发表于《国际肾脏》(Kidney Int)杂志。 研究纳入平均年龄为48岁的患者49例(男性:女性=3.5:1),以更新对感染性心内膜炎相关GN的认知情况。 结果为,心内膜炎相关GN最常见的表现为AKI。超过半数的患者之前无已知的心脏异常。最常见的合并症为心脏瓣膜疾

美国学者研究发现,心内膜炎相关肾小球肾炎(GN)最常见的表现为急性肾损伤(AKI),且并发金黄色葡萄球菌三尖瓣感染。论文1月21日发表于《国际肾脏》(Kidney Int)杂志。

研究纳入平均年龄为48岁的患者49例(男性:女性=3.5:1),以更新对感染性心内膜炎相关GN的认知情况。

结果为,心内膜炎相关GN最常见的表现为AKI。超过半数的患者之前无已知的心脏异常。最常见的合并症为心脏瓣膜疾病(30%)、静脉药瘾(29%)、丙肝(20%)和糖尿病(18%)。心脏瓣膜感染为三尖瓣、二尖瓣和主动脉瓣者分别达43%、33%和29%。两种最常见的感染细菌为葡萄球菌(53%)和链球菌(23%)。受检患者中存在低补体血症者达56%、抗中性粒细胞胞浆抗体(ANCA)阳性者达28%。最常见的肾活检发现为坏死和新月体GN(53%)。所有病例都有明显的C3沉积。

原始出处:

Boils CL1, Nasr SH2, Walker PD1, Couser WG3, Larsen CP1.Update on endocarditis-associated glomerulonephritis.Kidney Int. 2015 Jan 21. doi: 10.1038/ki.2014.424. [Epub ahead of print]

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    2015-07-29 sundong

    心内膜炎会加重ckd

    0

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    2015-04-11 x35042875

    轻度肾脏疾病对母亲和婴儿可能会增加孕期风险

    0

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    2015-03-05 lovetcm

    交叉学科研究

    0

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    2015-02-17 chinayinhan

    已阅

    0

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    2015-02-05 gwc389

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