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Nanomaterials:TC/PG纳米复合材料可持续抗菌用于临床感染的控制

2019-07-26 sunshine medsci

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具有持续药物释放性能的抗微生物材料的开发具有重要意义。 氧化石墨烯（GO）被认为是理想的药物载体。 在该研究中，将盐酸四环素（TC）加载到聚乙烯亚胺官能化的GO（PG）上以制备TC/PG纳米复合材料。通过zeta电位，TEM，FTIR和拉曼分析证实了制造的成功。TC/PG纳米复合材料显示出受控且持续的药物释放行为，并且采用伪二级动力学模型来说明释放机制。使用针对大肠杆菌和金黄色葡萄球菌的纸盘扩散法

具有持续药物释放性能的抗微生物材料的开发具有重要意义。 氧化石墨烯（GO）被认为是理想的药物载体。

在该研究中，将盐酸四环素（TC）加载到聚乙烯亚胺官能化的GO（PG）上以制备TC/PG纳米复合材料。通过zeta电位，TEM，FTIR和拉曼分析证实了制造的成功。TC/PG纳米复合材料显示出受控且持续的药物释放行为，并且采用伪二级动力学模型来说明释放机制。使用针对大肠杆菌和金黄色葡萄球菌的纸盘扩散法研究抗菌活性。结果显示，TC / PG纳米复合材料表现出很好的细菌抑制性能。

总之，该研究结果表明，制备的具有有效抗菌活性的TC/PG纳米复合材料在抗菌应用中具有很大的潜力。

原始出处：

Jiang L, Zhu Z, et al., Facile Construction of Functionalized GO Nanocomposites with Enhanced Antibacterial Activity. Nanomaterials (Basel). 2019 Jun 26;9(7). pii: E913. doi: 10.3390/nano9070913.

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