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Cell Tissue Res：从鲫鱼卵中分离的唾液酸糖蛋白通过刺激间充质干细胞促进成骨细胞分化促进骨生成

2019-02-05 MedSci MedSci原创

鲫鱼唾液酸
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在这项研究中，我们探讨鲫鱼卵（Ca-SGP）唾液酸糖蛋白的促成骨作用是否涉及间充质干细胞（MSCs）。使用Ca-SGP处理去卵巢的骨质疏松小鼠，可增加骨形成，减少脂肪组织形成。由于MSCs是成骨细胞和脂肪细胞的常见祖细胞，我们从Ca-SGP处理的小鼠中分离出MSCs，发现它们倾向于分化为成骨细胞而非脂肪细胞，正如茜素红和油红O染色所显示。为了进一步探索Ca-SGP对MSCs的作用，我们从健康小鼠中

在这项研究中，我们探讨鲫鱼卵（Ca-SGP）唾液酸糖蛋白的促成骨作用是否涉及间充质干细胞（MSCs）。

使用Ca-SGP处理去卵巢的骨质疏松小鼠，可增加骨形成，减少脂肪组织形成。由于MSCs是成骨细胞和脂肪细胞的常见祖细胞，我们从Ca-SGP处理的小鼠中分离出MSCs，发现它们倾向于分化为成骨细胞而非脂肪细胞，正如茜素红和油红O染色所显示。为了进一步探索Ca-SGP对MSCs的作用，我们从健康小鼠中分离出MSCs，并在体外用Ca-SGP处理。结果发现，Ca-SGP促进MSCs分化为成骨细胞。此外，Ca-SGP促进成骨并减少青春期小鼠骨髓腔内的脂肪。

总之，该研究结果首次表明，Ca-SGP通过刺激MSCs促成成骨细胞促进成骨。

原始出处：

Mao L, Wang M, et al., Sialoglycoprotein isolated from Carassius auratus eggs promotes osteogenesis by stimulating mesenchymal stem cells to commit to osteoblast differentiation. Cell Tissue Res. 2019 Feb 4. doi: 10.1007/s00441-018-2976-x. 

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    2019-11-09 h.y200607_23674418

    #间充质干细#

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    2019-07-04 zhaozhouchifen

    #Cell#

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    2019-10-09 xuyu

    #Tissue#

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352010, encodeId=07391352010e4, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495135, encodeId=59ae1495135f3, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570262, encodeId=fee615e02626a, content=<a href='/topic/show?id=a66ae7809b1' target=_blank style='color:#2F92EE;'>#细胞分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77809, encryptionId=a66ae7809b1, topicName=细胞分化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=653c15636865, createdName=karmond, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=)]
    2019-05-14 维他命

    #CEL#

    0

  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352010, encodeId=07391352010e4, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495135, encodeId=59ae1495135f3, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570262, encodeId=fee615e02626a, content=<a href='/topic/show?id=a66ae7809b1' target=_blank style='color:#2F92EE;'>#细胞分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77809, encryptionId=a66ae7809b1, topicName=细胞分化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=653c15636865, createdName=karmond, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=)]
    2019-02-19 ms2694732865965676

    #唾液酸#

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352010, encodeId=07391352010e4, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495135, encodeId=59ae1495135f3, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570262, encodeId=fee615e02626a, content=<a href='/topic/show?id=a66ae7809b1' target=_blank style='color:#2F92EE;'>#细胞分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77809, encryptionId=a66ae7809b1, topicName=细胞分化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=653c15636865, createdName=karmond, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=)]
    2019-02-08 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352010, encodeId=07391352010e4, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495135, encodeId=59ae1495135f3, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, 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    2019-02-08 yjs木玉

    学习学习学习学习

    0

  8. 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createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570262, encodeId=fee615e02626a, content=<a href='/topic/show?id=a66ae7809b1' target=_blank style='color:#2F92EE;'>#细胞分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77809, encryptionId=a66ae7809b1, topicName=细胞分化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=653c15636865, createdName=karmond, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=)]
    2019-02-07 zhaojie88

    #成骨#

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352010, encodeId=07391352010e4, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495135, encodeId=59ae1495135f3, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570262, encodeId=fee615e02626a, content=<a href='/topic/show?id=a66ae7809b1' target=_blank style='color:#2F92EE;'>#细胞分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77809, encryptionId=a66ae7809b1, topicName=细胞分化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=653c15636865, createdName=karmond, createdTime=Thu Feb 07 14:27:00 CST 2019, time=2019-02-07, status=1, ipAttribution=)]
    2019-02-07 zhaojie88

    #骨细胞#

    0

  10. 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    2019-02-07 karmond

    #细胞分化#

    0

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