Int J Mol Sci:氧化铝/氧化锆复合材料植入物表面涂覆生物活性玻璃可有效诱导成骨

2019-02-13 MedSci MedSci原创

实现植入物的稳定骨整合是现代整形外科手术所面临的巨大挑战之一。髋关节假体的陶瓷髋臼杯的固定通常需要使用具有穿透宿主骨盆骨的螺钉或钉的金属壳来实现。在植入物表面上沉积生物活性涂层以与骨接触可能是促进更“生理”骨整合的一种有价值的策略。在这项工作中,通过两种不同的方法,即海绵复制和激光熔覆,在氧化铝/氧化锆复合材料植入物的顶部制造生物活性玻璃多孔涂层。涂覆的样品在Kokubo的模拟体液(SBF)中进行

实现植入物的稳定骨整合是现代整形外科手术所面临的巨大挑战之一。髋关节假体的陶瓷髋臼杯的固定通常需要使用具有穿透宿主骨盆骨的螺钉或钉的金属壳来实现。在植入物表面上沉积生物活性涂层以与骨接触可能是促进更“生理”骨整合的一种有价值的策略。

在这项工作中,通过两种不同的方法,即海绵复制和激光熔覆,在氧化铝/氧化锆复合材料植入物的顶部制造生物活性玻璃多孔涂层。涂覆的样品在Kokubo的模拟体液(SBF)中进行浸泡研究以评估体外生物活性,并且发现其具有优异的羟基磷灰石形成能力,这是允许与骨结合的关键。使用间充质干细胞和成骨细胞样细胞的生物学试验揭示两种类型材料具有良好生物相容性。此外,海绵样的涂层在10天时诱导了更高水平的矿化。

总体而言,这些结果非常有前途,并鼓励对这些材料进行进一步研究。

原始出处:

Baino F, Minguella-Canela J, et al., In Vitro Assessment of Bioactive Glass Coatings on Alumina/Zirconia Composite Implants for Potential Use in Prosthetic Applications. Int J Mol Sci. 2019 Feb 8;20(3). pii: E722. doi: 10.3390/ijms20030722.

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    2019-02-15 zhaojie88
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2005185, encodeId=59b42005185fc, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Fri Mar 22 05:49:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054531, encodeId=3612205453155, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Aug 29 08:49:00 CST 2019, time=2019-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352029, encodeId=f1451352029b5, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Feb 15 07:49:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459740, encodeId=54291459e4080, content=<a href='/topic/show?id=00da63996ea' target=_blank style='color:#2F92EE;'>#氧化锆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63996, encryptionId=00da63996ea, topicName=氧化锆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=facd6195692, createdName=medsci248, createdTime=Fri Feb 15 07:49:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490904, encodeId=7f281490904e0, content=<a href='/topic/show?id=fb916268636' target=_blank style='color:#2F92EE;'>#植入物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62686, encryptionId=fb916268636, topicName=植入物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38628846382, createdName=linagood, createdTime=Fri Feb 15 07:49:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520557, encodeId=ae70152055e13, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Fri Feb 15 07:49:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360560, encodeId=9cc53605607a, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Wed Feb 13 17:21:00 CST 2019, time=2019-02-13, status=1, ipAttribution=)]
    2019-02-15 jiyangfei
  7. [GetPortalCommentsPageByObjectIdResponse(id=2005185, encodeId=59b42005185fc, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Fri Mar 22 05:49:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054531, encodeId=3612205453155, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Aug 29 08:49:00 CST 2019, time=2019-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352029, encodeId=f1451352029b5, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Feb 15 07:49:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459740, encodeId=54291459e4080, content=<a href='/topic/show?id=00da63996ea' target=_blank style='color:#2F92EE;'>#氧化锆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63996, encryptionId=00da63996ea, topicName=氧化锆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=facd6195692, createdName=medsci248, createdTime=Fri Feb 15 07:49:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490904, encodeId=7f281490904e0, content=<a href='/topic/show?id=fb916268636' target=_blank style='color:#2F92EE;'>#植入物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62686, encryptionId=fb916268636, topicName=植入物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38628846382, createdName=linagood, createdTime=Fri Feb 15 07:49:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520557, encodeId=ae70152055e13, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Fri Feb 15 07:49:00 CST 2019, time=2019-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360560, encodeId=9cc53605607a, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Wed Feb 13 17:21:00 CST 2019, time=2019-02-13, status=1, ipAttribution=)]
    2019-02-13 329523732

    不错

    0