Chest:阻塞性睡眠呼吸暂停影响急症患者预后

2014-04-04 佚名 dxy

在美国,每年有超过100万人因肺炎而住院,住院死亡率达到4%-9%。肺炎的并发症包括脓胸、败血症、急性呼吸窘迫综合征和呼吸衰竭等。阻塞性睡眠呼吸暂停(OSA)以睡眠中上呼吸道反复塌陷、阻塞为特征,可使患者频繁发生低通气、呼吸暂停和血氧饱和度下降。女性中度OSA的患病率约为2%-7%,而男性则为7%-14%。 已知OSA与患者术后呼吸系统并发症风险增加相关,但两者间的联系对急症患者预后的影响尚不明确

在美国,每年有超过100万人因肺炎而住院,住院死亡率达到4%-9%。肺炎的并发症包括脓胸、败血症、急性呼吸窘迫综合征和呼吸衰竭等。阻塞性睡眠呼吸暂停(OSA)以睡眠中上呼吸道反复塌陷、阻塞为特征,可使患者频繁发生低通气、呼吸暂停和血氧饱和度下降。女性中度OSA的患病率约为2%-7%,而男性则为7%-14%。

已知OSA与患者术后呼吸系统并发症风险增加相关,但两者间的联系对急症患者预后的影响尚不明确。来自美国马萨诸塞州斯普林菲尔德护理研究质量中心贝斯塔特医学中心的Lindenauer等人进行的一项回顾性队列研究显示,OSA与肺炎患者初期机械通气、临床恶化和更多资源使用相关,但院内死亡率却有所下降。文章近期发表在Chest杂志上。

研究共纳入250970名肺炎患者,其中15569名(6.2%)伴有OSA。患者年龄≥18岁,平均为71岁,53%为女性,约2/3为白人。结果显示,与未患OSA的患者相比,OSA患者更年轻(63岁比72岁),男性(53% 对 46%)、已婚(46% 对 38%)、肥胖(38% 对6%)、慢性肺病(68% 对 47%)及心衰(28% 对 19%)者更多。OSA患者入院时需要有创(18.1% 对9.3%)或无创(28.8% 对6.8%)通气治疗的可能性更大。

在校正多变量后,与未患OSA的肺炎患者相比,OSA患者在入院第三天及以后转入重症监护室的风险、初期插管风险均增加,其比值比(OR)分别为1.54和1.68;治疗后幸存者住院时间及花费也分别有14%及22%的增加;但其住院死亡率却有所下降,OR为0.96。

研究表明,在因肺炎住院的患者中,OSA使患者初始机械通气需求增加,临床恶化风险上升,卫生资源使用更多,但住院患者的死亡风险却有所下降。

原始出处

Lindenauer PK, Stefan MS, Johnson KG, Priya A, Pekow PS, Rothberg MB.Prevalence, Treatment and Outcomes Associated with Obstructive Sleep Apnea Among Patients Hospitalized with Pneumonia.Chest. 2013 Dec 26

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    2015-01-14 Smile2680
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    2014-08-31 wjywjy
  5. [GetPortalCommentsPageByObjectIdResponse(id=2050397, encodeId=7e37205039e20, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Tue Dec 30 00:13:00 CST 2014, time=2014-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691826, encodeId=fdb7169182635, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Jan 30 17:13:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929209, encodeId=7dae1929209a1, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Wed Jan 14 03:13:00 CST 2015, time=2015-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1649264, encodeId=e8001649264aa, content=<a href='/topic/show?id=1c8152531f0' target=_blank style='color:#2F92EE;'>#急症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52531, encryptionId=1c8152531f0, topicName=急症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c33023794178, createdName=wjywjy, createdTime=Sun Aug 31 01:13:00 CST 2014, time=2014-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988972, encodeId=346e19889e200, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Jul 26 02:13:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596432, encodeId=244b159643230, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Apr 06 05:13:00 CST 2014, time=2014-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696628, encodeId=4792169662859, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sat Feb 21 05:13:00 CST 2015, time=2015-02-21, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2050397, encodeId=7e37205039e20, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Tue Dec 30 00:13:00 CST 2014, time=2014-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691826, encodeId=fdb7169182635, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Jan 30 17:13:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929209, encodeId=7dae1929209a1, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Wed Jan 14 03:13:00 CST 2015, time=2015-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1649264, encodeId=e8001649264aa, content=<a href='/topic/show?id=1c8152531f0' target=_blank style='color:#2F92EE;'>#急症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52531, encryptionId=1c8152531f0, topicName=急症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c33023794178, createdName=wjywjy, createdTime=Sun Aug 31 01:13:00 CST 2014, time=2014-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988972, encodeId=346e19889e200, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Jul 26 02:13:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596432, encodeId=244b159643230, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Apr 06 05:13:00 CST 2014, time=2014-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696628, encodeId=4792169662859, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sat Feb 21 05:13:00 CST 2015, time=2015-02-21, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2050397, encodeId=7e37205039e20, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Tue Dec 30 00:13:00 CST 2014, time=2014-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691826, encodeId=fdb7169182635, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Fri Jan 30 17:13:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929209, encodeId=7dae1929209a1, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Wed Jan 14 03:13:00 CST 2015, time=2015-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1649264, encodeId=e8001649264aa, content=<a href='/topic/show?id=1c8152531f0' target=_blank style='color:#2F92EE;'>#急症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52531, encryptionId=1c8152531f0, topicName=急症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c33023794178, createdName=wjywjy, createdTime=Sun Aug 31 01:13:00 CST 2014, time=2014-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988972, encodeId=346e19889e200, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Jul 26 02:13:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596432, encodeId=244b159643230, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Apr 06 05:13:00 CST 2014, time=2014-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696628, encodeId=4792169662859, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sat Feb 21 05:13:00 CST 2015, time=2015-02-21, status=1, ipAttribution=)]
    2015-02-21 tomyang96