Circulation:右室射血分数可作为缺血性心肌病的预测及预后评估指标

2016-09-02 MedSci MedSci原创

右室射血分数可作为一个独立的二尖瓣返流严重程度的预测指标。降低的右室射血分数与缺血性心肌病患者增加的死亡率相关;然而,这种关联可能在患者接受二尖瓣修复或更换后减弱。

正如左室射血分数在心脏病患者心功能的评估中起着重要作用,同样,缺血性心肌病患者降低的右室射血分数预示着患者预后较差,已有研究表明二尖瓣返流和右室射血分数存在相关性。来自波士顿哈佛医学院的Sabe教授评试图评估二尖瓣修复或更换和右心室功能及死亡率之间的关系。 

研究者纳入了2002年至2008年间经心脏磁共振成像诊断的588例(平均年龄为63±11岁,75%为男性)缺血性心肌病患者。收集了研究对象的基线特征、左室射血分数、二尖瓣返流严重程度、治疗方式、疤痕大小和右室射血分数。通过多元线性回归和Cox比例风险模型分别评估了二尖瓣返流和右室射血分数之间以及右室射血分数和死亡率之间的关联。

研究者发现:二尖瓣返流的严重程度与右室射血分数存在着相关性。在5.7年的中位随访时间内,共有240例研究对象死亡。进行多变量调整后,研究者观察到右室射血分数每减少10%,研究对象的死亡风险相应的增加17%P = 0.008)。尽管在未进行二尖瓣修复的患者中,降低的右室射血分数与预后不良相关(风险比为1.2895%置信区间为1.12–1.47P0.001),而在二尖瓣修复或置换组,右室射血分数与死亡率之间不存在相关关系。 

研究结果表明:右室射血分数可作为一个独立的二尖瓣返流严重程度的预测指标。降低的右室射血分数与缺血性心肌病患者增加的死亡率相关;然而,这种关联可能在患者接受二尖瓣修复或更换后减弱。 

原始出处:


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    2016-10-12 1e118bd5m58(暂无匿称)

    不错的文章

    0

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    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

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    2016-09-05 刘煜

    学习了谢谢。

    0

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    2016-09-03 大旺旺

    学习了啊

    0