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J Cell Physiol：miR-409-5p通过靶向Lrp-8负调节Wnt /β连环蛋白信号传导通路

2019-06-13 不详 网络

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Wnt信号通路在骨骼发育的各个方面起着至关重要的作用，包括成骨细胞生成和破骨细胞生成。Wnt信号传导途径的失活导致骨相关病症，而Wnt信号传导途径的激活可以治愈骨质疏松症等骨病变。已经鉴定了某些mi-RNA与Wnt信号分子交联以调节骨生成。在本研究中，我们报道了通过靶向Lrp-8鉴定miR-409-5p作为成骨抑制因子，Lrp-8是Wnt信号传导的正效应物。研究表明，过表达miR-409-5p抑制

Wnt信号通路在骨骼发育的各个方面起着至关重要的作用，包括成骨细胞生成和破骨细胞生成。Wnt信号传导途径的失活导致骨相关病症，而Wnt信号传导途径的激活可以治愈骨质疏松症等骨病变。已经鉴定了某些mi-RNA与Wnt信号分子交联以调节骨生成。在本研究中，我们报道了通过靶向Lrp-8鉴定miR-409-5p作为成骨抑制因子，Lrp-8是Wnt信号传导的正效应物。

研究表明，过表达miR-409-5p抑制成骨细胞分化，而抗miR-409阻碍miR-409-5p表达促进成骨细胞功能和基质矿化。使用诸如目标扫描和3'-UTR荧光素酶报告基因测定的工具，Lrp-8被确认为miR-409-5p的直接靶标。通过过表达miR-409-5p，观察到经典Wnt /β连环蛋白信号传导的抑制。由于卵巢切除的雌激素缺乏的Balb/c小鼠中miR-409-5p的沉默恢复了骨小梁微结构的丧失并抑制了骨吸收，这些观察结果得到了加强。

因此，靶向miR-409-5p可能有助于在绝经后骨质疏松症等病症中增加骨密度。

原始出处：

Prakash R, John AA, Singh D. miR-409-5p negatively regulates Wnt/Beta catenin signaling pathway by targeting Lrp-8. J Cell Physiol. 2019 Jun 4. doi: 10.1002/jcp.28919. 

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