G蛋白偶联受体激动剂OK-113:具有强效抗炎作用

2019-08-29 Allan MedSci原创

OKYO是一家专注于G蛋白偶联受体(GPCR)的生物技术公司。OKYO近日宣布,在小鼠的干眼病(DED)模型中,GPCR激动剂OK-113具有强效抗炎活性。这些临床前有效性数据将有助于启动2020年DED治疗的临床研究。

OKYO是一家专注于G蛋白偶联受体(GPCR)的生物技术公司。OKYO近日宣布,在小鼠的干眼病(DED)模型中,GPCR激动剂OK-113具有强效抗炎活性。这些临床前有效性数据将有助于启动2020DED治疗的临床研究。

DED是一种眼睛干涩的状态。其他的症状包括眼睛过敏、发红、多眼屎或是容易疲劳,也可能出现视线模糊的情况。症状可以从轻度且偶然出现,到重度且持续发生。在一些未经治疗的案例中,可能在角膜留下伤疤。DED是种常见眼疾,随着族群不同,发病率可能从5-34%不等。在高龄人口中,发病率可达70%。在中国,约有17%人口罹患此疾。


原始出处:

http://www.firstwordpharma.com/node/1662387#axzz5xwhWnSXE

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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