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Lancet：罕见虹膜尤文氏肉瘤-案例报道

2016-05-06 Mechront 译 MedSci原创

尤文氏肉瘤虹膜案例
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患者男，46岁，因左眼虹膜肉质粉红色病灶就诊。组织病理学检查：蓝色的小圆形细胞增殖，膜CD99阳性，EWSR1重排，符合尤文氏肉瘤。诊断明确。治疗：异环磷酰胺、阿霉素、长春新碱、依托泊苷治疗6个周期，随后钌-106局部放疗（对眼功能的保护作用优于手术），以及长春新碱、放线菌素-D和异环磷酰胺治疗8次，使患者的肉瘤完全缓解（如下图）。考虑到患者的年龄，阿霉素和依托泊苷的使用剂量减少了25%，在每个治

患者男，46岁，因左眼虹膜肉质粉红色病灶就诊。



组织病理学检查：蓝色的小圆形细胞增殖，膜CD99阳性，EWSR1重排，符合尤文氏肉瘤。诊断明确。

治疗：异环磷酰胺、阿霉素、长春新碱、依托泊苷治疗6个周期，随后钌-106局部放疗（对眼功能的保护作用优于手术），以及长春新碱、放线菌素-D和异环磷酰胺治疗8次，使患者的肉瘤完全缓解（如下图）。



考虑到患者的年龄，阿霉素和依托泊苷的使用剂量减少了25%，在每个治疗周期后予以了聚乙二醇化非格司亭。没有发生与治疗相关的不良反应。

尤文氏肉瘤（ES）是小圆形细胞的低分化的恶性肿瘤，是骨肿瘤的一种。本例发生于虹膜的ES是非常罕见的！

原始出处：

Anna H Roukens, Judith R Kroep,et al.Primary Ewing sarcoma of the iris.The Lancet.DOI: http://dx.doi.org/10.1016/S0140-6736(13)60183-X

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    2016-08-02 howi

    #Lancet#

    0

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    2016-09-17 1e10c84am36(暂无匿称)

    不错哦，会学到很多，喜欢梅斯医学文章

    0

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    2016-09-14 1e10c84am36(暂无匿称)

    文章不错，值得拜读

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 01 08:48:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106955, encodeId=290e10695580, content=深入学习，好文值得点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 20:33:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2031968, encodeId=519e20319683f, content=<a href='/topic/show?id=f3934e272e8' target=_blank style='color:#2F92EE;'>#尤文氏肉瘤#</a>, 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encodeId=a6948e7452c, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87746, encodeId=6b198e74666, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87747, encodeId=d3188e7471c, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-09-01 ylzr123

    好文，值得学习，赞！

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87747, encodeId=d3188e7471c, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-08-29 ylzr123

    深入学习，好文值得点赞！

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87747, encodeId=d3188e7471c, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2017-03-10 neurowu

    #尤文氏肉瘤#

    0

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beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47272, encryptionId=f3934e272e8, topicName=尤文氏肉瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Fri Mar 10 20:35:00 CST 2017, time=2017-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754774, encodeId=b7841e54774ac, content=<a href='/topic/show?id=efff8856504' target=_blank style='color:#2F92EE;'>#虹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88565, encryptionId=efff8856504, topicName=虹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab9a36785616, createdName=LSJ123, createdTime=Thu Oct 20 21:35:00 CST 2016, time=2016-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87745, encodeId=a6948e7452c, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87746, encodeId=6b198e74666, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87747, encodeId=d3188e7471c, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-10-20 LSJ123

    #虹膜#

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87747, encodeId=d3188e7471c, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-05-31 wxsession1cb66d13

    强

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87747, encodeId=d3188e7471c, content=强, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xUVV4sJ3WJibPFtGrPW2ib87gibBJRccg43ialdQBh22x7FztexKwUp3DGN2bKCzRTXKFc9IPRYUwQiaQ/0, createdBy=72a41730948, createdName=wxsession1cb66d13, createdTime=Tue May 31 09:30:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-05-31 wxsession1cb66d13

    强

    0

  10. 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    2016-05-31 wxsession1cb66d13

    强

    0

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