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Lancet neurology：神经痛药物治疗系统性回顾和荟萃分析研究

2015-01-11 MedSci MedSci原创

神经痛荟萃

研究背景： 神经痛的药物治疗推荐指南应根据新药治疗、临床试验以及标准的疗效评估循证医学证据得以修正。应用推荐等级的评估、制定与评价系统（GRADE），研究人员根据系统性回顾和荟萃分析，针对神经痛的药物治疗，重新修正了神经痛特殊管理推荐指南（Special Interest Group on Neuropathic Pain，NeuPSIG）。 研究方法： 自2013年4月至201

研究背景： 神经痛的药物治疗推荐指南应根据新药治疗、临床试验以及标准的疗效评估循证医学证据得以修正。应用推荐等级的评估、制定与评价系统（GRADE），研究人员根据系统性回顾和荟萃分析，针对神经痛的药物治疗，重新修正了神经痛特殊管理推荐指南（Special Interest Group on Neuropathic Pain，NeuPSIG）。 研究方法： 自2013年4月至2014年1月，国际疼痛研究协会的NeuPSIG工作组针对神经痛的口服和局部药物治疗，进行了系统性回顾和荟萃分析研究，收集自1966年经同行评议发表在期刊上的研究论文数据、在ClinicalTrials.gov注册的未发表的临床试验数据以及制药公司网站提供的数据。研究人员以缓解50%疼痛所需治疗次数（number needed to treat，NTT）为主要的评估指标，并评估了出版资料的偏移；采用固定效应模型计算NTT。 研究结果： 229项临床试验参与荟萃分析。出版资料的偏移分析提示夸大的治疗效应为10%。发表在同行评议期刊上的药物疗效大于未发布的研究数据所提示的疗效（r2 9.3%，p=0·009）。研究结果普

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    2015-02-20 howi

    #Lancet#

    0

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    2015-03-22 仁心济世

    #荟萃#

    0

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    2015-09-28 yinhl1978

    #Neurol#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1827970, encodeId=eb46182e970a4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Feb 20 23:01:00 CST 2015, time=2015-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681280, encodeId=535b168128067, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 22 06:01:00 CST 2015, time=2015-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999485, encodeId=ea201999485bb, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Sep 28 12:01:00 CST 2015, time=2015-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19582, encodeId=7dcf19582f0, content=就想写个meta分析，但是好多不懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Mon Apr 06 00:44:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19583, encodeId=d21019583f1, content=支持继续, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Mon Apr 06 00:44:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19584, encodeId=64c119584a7, content=嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Mon Apr 06 00:44:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016912, encodeId=551f201691259, content=<a href='/topic/show?id=9760e69058c' target=_blank style='color:#2F92EE;'>#系统性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76905, encryptionId=9760e69058c, topicName=系统性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b9b368, createdName=qingrejiedu, createdTime=Wed Aug 12 00:01:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836864, encodeId=ba491836864ef, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Fri Nov 20 15:01:00 CST 2015, time=2015-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540803, encodeId=0ed415408036b, content=<a href='/topic/show?id=ac8de440615' target=_blank style='color:#2F92EE;'>#神经痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74406, encryptionId=ac8de440615, topicName=神经痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d8213287489, createdName=贵阳, createdTime=Tue Jan 13 07:01:00 CST 2015, time=2015-01-13, status=1, ipAttribution=)]
    2015-04-06 清氺訫

    就想写个meta分析，但是好多不懂

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1827970, encodeId=eb46182e970a4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Feb 20 23:01:00 CST 2015, time=2015-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681280, encodeId=535b168128067, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Mar 22 06:01:00 CST 2015, time=2015-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999485, encodeId=ea201999485bb, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Sep 28 12:01:00 CST 2015, time=2015-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19582, encodeId=7dcf19582f0, content=就想写个meta分析，但是好多不懂, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Mon Apr 06 00:44:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19583, encodeId=d21019583f1, content=支持继续, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Mon Apr 06 00:44:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19584, encodeId=64c119584a7, content=嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Mon Apr 06 00:44:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2016912, encodeId=551f201691259, content=<a href='/topic/show?id=9760e69058c' target=_blank style='color:#2F92EE;'>#系统性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76905, encryptionId=9760e69058c, topicName=系统性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b9b368, createdName=qingrejiedu, createdTime=Wed Aug 12 00:01:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836864, encodeId=ba491836864ef, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Fri Nov 20 15:01:00 CST 2015, time=2015-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540803, encodeId=0ed415408036b, content=<a href='/topic/show?id=ac8de440615' target=_blank style='color:#2F92EE;'>#神经痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74406, encryptionId=ac8de440615, topicName=神经痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0d8213287489, createdName=贵阳, createdTime=Tue Jan 13 07:01:00 CST 2015, time=2015-01-13, status=1, ipAttribution=)]
    2015-04-06 清氺訫

    支持继续

    0

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    2015-04-06 清氺訫

    嗯

    0

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    2015-08-12 qingrejiedu

    #系统性#

    0

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    2015-11-20 fangcong

    #荟萃分析#

    0

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    2015-01-13 贵阳

    #神经痛#

    0

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