NEJM:易被误诊为癌症的脾组织植入症-案例报道

2016-05-19 Mechront 译 MedSci原创

患者女,62岁,进行性呼吸困难。有每年40包烟的吸烟史。胸片:沿左侧膈肌有结节(图A,箭头),癌症不除外。此外患者还有肺气肿和轻度脊柱侧凸。既往史:28年前胸腹部枪伤,导致肝脏、左侧膈肌和脾损伤,进行开腹脾切除术。CT:左侧(图B,箭头)可见数个小的基底部的胸膜结节,以及横隔膜缺陷和脾床结节,与先前脾切除表现一致。通过锝-99m标记热损伤红细胞扫描证实了结节为脾组织,患者诊断为脾组织植入症。医生建

患者女,62岁,进行性呼吸困难。有每年40包烟的吸烟史。

胸片:沿左侧膈肌有结节(图A,箭头),癌症不除外。此外患者还有肺气肿和轻度脊柱侧凸。



既往史:28年前胸腹部枪伤,导致肝脏、左侧膈肌和脾损伤,进行开腹脾切除术。

CT:左侧(图B,箭头)可见数个小的基底部的胸膜结节,以及横隔膜缺陷和脾床结节,与先前脾切除表现一致。



通过锝-99m标记热损伤红细胞扫描证实了结节为脾组织,患者诊断为脾组织植入症。

医生建议本例患者对荚膜细菌进行免疫抵抗,对于患者的慢性阻塞性肺疾病,采用了吸入剂治疗,并疗效不错。

脾组织植入症指整个腹部的腹膜表面有多个小的脾组织在散在的部位生长。这起因于脾脏外伤破裂后脾组织碎块的散播和自体移植。脾脏损伤后,脾组织自体移植是罕见的。脾创伤后,若脾被膜撕裂,脾组织可种植于腹膜。脾细胞的成功种植,其后生长成含有脾细胞和脾组织的脾结节。

脾组织植入症一般没有症状,常在以后不相关的情况下剖腹时被发现。可引发腹部或盆腔疼痛,症状类似于子宫内膜异位;也可导致粘连而成为肠梗阻;更有可能被误诊为癌症结节。

脾组织植入症的确诊微创检查:99mtc-硫胶体、铟111标记血小板,99mTc热损伤红细胞或99mTc白细胞扫描。Fe2O3MRI是另一种诊断方法,如果出现多发性脾结节,在磁共振成像上,它们的强度会有一致性。

原始出处:

Matlawene Mpe, M.B., Ch.B., and Cameron Schauer, M.B., Ch.B.Splenosis Mimicking Cancer.Splenosis Mimicking Cancer.N Engl J Med 2016; 374:1965May 19, 2016DOI: 10.1056/NEJMicm1512086

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    2016-09-30 1e10c84am36(暂无匿称)

    拜读,好文

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  2. [GetPortalCommentsPageByObjectIdResponse(id=138136, encodeId=35bc138136c7, content=拜读,好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:18:14 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129830, encodeId=9d0912983043, content=好文,从这里学习了好多新知识,新信息。赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 06:26:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106621, encodeId=10b510662112, content=深度好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 07:53:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520311, encodeId=c378152031169, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Sat May 21 14:12:00 CST 2016, time=2016-05-21, status=1, ipAttribution=)]
    2016-09-18 ylzr123

    好文,从这里学习了好多新知识,新信息。赞了!

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    2016-08-29 ylzr123

    深度好文,值得学习,赞!

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    2016-05-21 jiyangfei