J Periodontal Res:患牙周炎吸烟者的临床参数与宿主反应之间的相互作用

2017-07-29 MedSci MedSci原创

牙周疾病是导致牙齿缺失的主要公共健康问题,也被证明与几种慢性全身性疾病有关。吸烟是许多系统性疾病以及牙周炎发展的主要危险因素。虽然吸烟者发展成牙周炎导致牙齿缺失的风险明显增加,但是与吸烟有关的疾病的易感性也不同。这项调查的重点是确定四个广泛变量的差异,包括:(i)宿主反应分子; (二)牙周临床参数; (iii)对牙周病原体和口腔共生细菌的抗体应答;和(iv)在有(n = 171)和无(n = 11

牙周疾病是导致牙齿缺失的主要公共健康问题,也被证明与几种慢性全身性疾病有关。吸烟是许多系统性疾病以及牙周炎发展的主要危险因素。虽然吸烟者发展成牙周炎导致牙齿缺失的风险明显增加,但是与吸烟有关的疾病的易感性也不同。这项调查的重点是确定四个广泛变量的差异,包括:(i)宿主反应分子; (二)牙周临床参数; (iii)对牙周病原体和口腔共生细菌的抗体应答;和(iv)在有(n = 171)和无(n = 117)牙周炎的吸烟者群体中的其他感兴趣的变量。

材料与方法:贝叶斯网络结构学习(BNSL)技术被用于研究四大变量之间的潜在关联和相互作用。

BNSL揭示了两个广泛的社区有牙周炎和无牙周炎,吸烟者群体之间的拓扑明显不同,。在所得网络中的边缘置信度也显示在牙周炎和非牙周炎组内和组间的显着变化。

结果验证了已知的联系,发现最新优先级,可能需要进一步的研究和新的假设。牙周炎时,细菌的临床变量和抗体谱之间的相互作用特别明显,并且由牙龈卟啉单胞菌的抗体应答谱介导。

原始出处:

R. Nagarajan, C. S. Miller, D. Dawson III, et al. Cross-talk between clinical and host-response parameters of periodontitis in smokers. Journal of periodontal research. 2017 June. doi: 10.1111/jre.12397

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    2018-04-29 medscijoin
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    2017-07-31 ylz8405

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