Future Microbiol:急诊中感染患者致病原的识别

2020-02-19 不详 网络

在急诊科(ED)中,感染对象的病原学识别至关重要。本研究中,研究人员使用新的流式细胞仪程序评估了13种与感染相关的生物标记。如果受试者在ED时出现发热症状,则对13种生物标志物的水平进行了测试,包括中性粒细胞上的CD64(nCD64)和单核细胞上的CD169(mCD169),并将其与临床记录进行比较。结果显示,在50名受试者中,有78%患有细菌感染,而8%有病毒感染。 nCD64对鉴定患有细菌感染

在急诊科(ED)中,感染对象的病原学识别至关重要。本研究中,研究人员使用新的流式细胞仪程序评估了13种与感染相关的生物标记。如果受试者在ED时出现发热症状,则对13种生物标志物的水平进行了测试,包括中性粒细胞上的CD64(nCD64)和单核细胞上的CD169(mCD169),并将其与临床记录进行比较。

结果显示,在50名受试者中,有78%患有细菌感染,而8%有病毒感染。 nCD64对鉴定患有细菌感染的受试者显示出82%的敏感性和91%的特异性。 在患有病毒感染的受试者中,单核细胞上的mCD169,HLA-ABC比和HLA-DR具有较高的值。

综上所述,该研究结果表明,生物标志物在改善ED的感染分层方面显示出令人欣喜的表现。

原始出处:

Bourgoin P, Lediagon G, et al., Flow cytometry evaluation of infection-related biomarkers in febrile subjects in the emergency department. Future Microbiol. 2020 Feb 17. doi: 10.2217/fmb-2019-0256. 

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