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Carbohydr Polym：新型生物材料可增强人间充质干细胞的分化

2018-10-06 MedSci MedSci原创

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藻酸盐（Alg）水凝胶是广为使用的天然生物材料，模仿细胞外基质（ECM）微环境并提供潜在的生物医学应用。尽管其具有优异的性质，如生物相容性、亲水性和离子交联，但缺乏固有的细胞粘附区域减少了其在组织工程中的细胞载体的应用。 在这里，我们通过整合Alg水凝胶和成纤维细胞衍生的基质（FDM）建立三维（3D）细胞培养系统。FDM包括细胞粘附基序、信号传导和物理机械信息，通过去细胞化过程通过避免不利的

藻酸盐（Alg）水凝胶是广为使用的天然生物材料，模仿细胞外基质（ECM）微环境并提供潜在的生物医学应用。尽管其具有优异的性质，如生物相容性、亲水性和离子交联，但缺乏固有的细胞粘附区域减少了其在组织工程中的细胞载体的应用。

在这里，我们通过整合Alg水凝胶和成纤维细胞衍生的基质（FDM）建立三维（3D）细胞培养系统。FDM包括细胞粘附基序、信号传导和物理机械信息，通过去细胞化过程通过避免不利的化学反应来制备。该信息整合生物材料（CiB）3D平台显示人骨髓间充质干细胞（hMSC）的细胞活力、增殖、软骨形成和成骨分化增加。结果表明，Alg/FDM水凝胶（CiB）基质为细胞粘附提供了良好的微环境，可以控制hMSCs向特定谱系的分化。

因此，这些结果表明Alg/FDM水凝胶基质作为组织再生的可行的3D培养系统的潜在应用。

原始出处：

Park MH, Subbiah R, et al., The three dimensional cues-integrated-biomaterial potentiates differentiation of human mesenchymal stem cells. Carbohydr Polym. 2018 Dec 15;202:488-496. doi: 10.1016/j.carbpol.2018.09.010. Epub 2018 Sep 6.

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    2019-03-06 1249857fm32暂无昵称

    #生物材#

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    2018-12-14 h.y200607_23674418

    #间充质干细#

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    2018-10-08 dongjia2013

    #生物材料#

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    2018-10-06 医者仁心5538

    学习了

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