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Mater Sci Eng C Mater Biol Appl：Zr基生物陶瓷的CS复合材料支架可用于骨组织工程的骨修复

2019-11-28 不详 网络

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与羟基磷灰石纳米粒子相比，基于锆（Zr）的生物陶瓷纳米粒子作为壳聚糖（CS）的填充材料用于开发复合支架的研究较少。这主要是由于纳米羟基磷灰石（nHA; Ca10（PO4）6（OH）2）与骨无机成分的生物学相似性。在这项研究中，我们比较了与nHA，纳米氧化锆（nZrO; ZrO2）和纳米锆酸钙（nCZ; CaZrO3）掺杂的CS复合支架的物理和生物学特性。在这项研究中，我们首次报道了CS-nCZ复合

与羟基磷灰石纳米粒子相比，基于锆（Zr）的生物陶瓷纳米粒子作为壳聚糖（CS）的填充材料用于开发复合支架的研究较少。这主要是由于纳米羟基磷灰石（nHA; Ca10（PO4）6（OH）2）与骨无机成分的生物学相似性。在这项研究中，我们比较了与nHA，纳米氧化锆（nZrO; ZrO2）和纳米锆酸钙（nCZ; CaZrO3）掺杂的CS复合支架的物理和生物学特性。在这项研究中，我们首次报道了CS-nCZ复合支架的性能。

使用冷冻干燥技术开发了多孔复合支架。复合支架的抗压强度和模量在50-55 KPa和0.75-0.95 MPa范围内，与单独使用CS的支架（28 KPa和0.25 MPa）相比明显更高（p <0.05），与CS-nHA，CS-nZrO和CS-nCZ支架相当。使用原子力显微镜（AFM）进行的峰力定量纳米力学标测（PFQNM）表明，复合材料的杨氏模量比仅CS高（p <0.001），并且在复合材料中该值相似。在骨组织再生应用中使用基于Zr的生物陶瓷材料的主要问题之一是它们对成骨细胞的响应较低。这项研究表明，与CS-nZrO相比，CS-nCZ支持前成骨细胞更高的增殖，其扩散与CS-nHA支架中的扩散更为相似。

综上所述，该研究结果表明，Zr基生物陶瓷的CS复合材料的物理和生物学特性与CS-nHA复合支架相当，因此CS-nCZ在未来骨组织工程中具有应用前景。

原始出处：

Gaihre B, Jayasuriya AC. Comparative investigation of porous nano-hydroxyapaptite/chitosan, nano-zirconia/chitosan and novel nano-calcium zirconate/chitosan composite scaffolds for their potential applications in bone regeneration. Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:330-339. doi: 10.1016/j.msec.2018.05.060. Epub 2018 May 18.

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    2020-10-24 redcrab

    #陶瓷#

    0

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    2020-04-29 ms4964546379600229

    #复合材料#

    0

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    2020-01-01 12498ebem31暂无昵称

    #Biol#

    0

  4. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed Apr 29 01:22:00 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767726, encodeId=a8ea1e6772644, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Jan 01 13:22:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076368, encodeId=b3a320e63686e, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Jul 10 08:22:00 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719508, encodeId=b47c1e1950893, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Sat Apr 18 12:22:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), 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createdName=sunylz, createdTime=Sat Jun 13 17:22:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935339, encodeId=9d3e193533911, content=<a href='/topic/show?id=dae2694960d' target=_blank style='color:#2F92EE;'>#生物陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69496, encryptionId=dae2694960d, topicName=生物陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sun Mar 29 13:22:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081578, encodeId=149b20815e859, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Apr 01 00:22:00 CST 2020, time=2020-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417210, encodeId=76f2141e2107c, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Sat Nov 30 07:22:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2020-07-10 diushouji

    #骨组织#

    0

  5. 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createdName=sunylz, createdTime=Sat Jun 13 17:22:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935339, encodeId=9d3e193533911, content=<a href='/topic/show?id=dae2694960d' target=_blank style='color:#2F92EE;'>#生物陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69496, encryptionId=dae2694960d, topicName=生物陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sun Mar 29 13:22:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081578, encodeId=149b20815e859, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Apr 01 00:22:00 CST 2020, time=2020-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417210, encodeId=76f2141e2107c, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Sat Nov 30 07:22:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2020-04-18 axin020

    #骨修复#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1776980, encodeId=e0731e769805a, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Sat Oct 24 14:22:00 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054551, encodeId=da7a2054551f3, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, 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encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Apr 01 00:22:00 CST 2020, time=2020-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417210, encodeId=76f2141e2107c, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Sat Nov 30 07:22:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2020-09-14 linagood

    #骨组织工程#

    0

  7. 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style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Jul 10 08:22:00 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719508, encodeId=b47c1e1950893, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Sat Apr 18 12:22:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070101, encodeId=6e5820e010109, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Sep 14 09:22:00 CST 2020, time=2020-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918935, encodeId=0001191893597, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jun 13 17:22:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935339, encodeId=9d3e193533911, content=<a href='/topic/show?id=dae2694960d' target=_blank style='color:#2F92EE;'>#生物陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69496, encryptionId=dae2694960d, topicName=生物陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sun Mar 29 13:22:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081578, encodeId=149b20815e859, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Apr 01 00:22:00 CST 2020, time=2020-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417210, encodeId=76f2141e2107c, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Sat Nov 30 07:22:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2020-06-13 sunylz

    #Bio#

    0

  8. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed Apr 29 01:22:00 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767726, encodeId=a8ea1e6772644, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Jan 01 13:22:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076368, encodeId=b3a320e63686e, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Jul 10 08:22:00 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719508, encodeId=b47c1e1950893, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Sat Apr 18 12:22:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070101, encodeId=6e5820e010109, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Sep 14 09:22:00 CST 2020, time=2020-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918935, encodeId=0001191893597, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jun 13 17:22:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935339, encodeId=9d3e193533911, content=<a href='/topic/show?id=dae2694960d' target=_blank style='color:#2F92EE;'>#生物陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69496, encryptionId=dae2694960d, topicName=生物陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sun Mar 29 13:22:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081578, encodeId=149b20815e859, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Apr 01 00:22:00 CST 2020, time=2020-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417210, encodeId=76f2141e2107c, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Sat Nov 30 07:22:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2020-03-29 晓辰

    #生物陶瓷#

    0

  9. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed Apr 29 01:22:00 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767726, encodeId=a8ea1e6772644, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Jan 01 13:22:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076368, encodeId=b3a320e63686e, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Jul 10 08:22:00 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719508, encodeId=b47c1e1950893, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Sat Apr 18 12:22:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070101, encodeId=6e5820e010109, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Sep 14 09:22:00 CST 2020, time=2020-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918935, encodeId=0001191893597, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jun 13 17:22:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935339, encodeId=9d3e193533911, content=<a href='/topic/show?id=dae2694960d' target=_blank style='color:#2F92EE;'>#生物陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69496, encryptionId=dae2694960d, topicName=生物陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sun Mar 29 13:22:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081578, encodeId=149b20815e859, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Apr 01 00:22:00 CST 2020, time=2020-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417210, encodeId=76f2141e2107c, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Sat Nov 30 07:22:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2020-04-01 spoonycyy

    #Eng#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1776980, encodeId=e0731e769805a, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Sat Oct 24 14:22:00 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054551, encodeId=da7a2054551f3, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed Apr 29 01:22:00 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767726, encodeId=a8ea1e6772644, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Jan 01 13:22:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076368, encodeId=b3a320e63686e, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Fri Jul 10 08:22:00 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719508, encodeId=b47c1e1950893, content=<a href='/topic/show?id=17641015914f' target=_blank style='color:#2F92EE;'>#骨修复#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101591, encryptionId=17641015914f, topicName=骨修复)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7a5232746261, createdName=axin020, createdTime=Sat Apr 18 12:22:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070101, encodeId=6e5820e010109, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Sep 14 09:22:00 CST 2020, time=2020-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918935, encodeId=0001191893597, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jun 13 17:22:00 CST 2020, time=2020-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935339, encodeId=9d3e193533911, content=<a href='/topic/show?id=dae2694960d' target=_blank style='color:#2F92EE;'>#生物陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69496, encryptionId=dae2694960d, topicName=生物陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5712500001, createdName=晓辰, createdTime=Sun Mar 29 13:22:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081578, encodeId=149b20815e859, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Apr 01 00:22:00 CST 2020, time=2020-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417210, encodeId=76f2141e2107c, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Sat Nov 30 07:22:00 CST 2019, time=2019-11-30, status=1, ipAttribution=)]
    2019-11-30 zhu_jun9838

    #组织工程#

    0

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