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Blood：体外光化学疗法(ECP)可明显改善Sezary综合征和真菌红皮病患者预后

2019-09-02 MedSci MedSci原创

体外光化学疗法ECPSezary综合征真菌红皮病
关注

目前已证实体外光化学疗法(ECP)对Sezary综合征(SS)和真菌红皮病(MF)患者具有治疗作用。为了检验ECP在现代新型治疗方法中的有效性，Crystal Gao等人对其医院65例确诊为SS或伴有血液受累的红皮性MF患者进行了回顾性分析。研究结点是以总体存活率(OS)和下一次治疗时间(TTNT)来评估患者的预后。

中心点：

体外光化学疗法可延长Sezary综合征/红皮真菌病患者的生存期、改善疾病控制。

Sezary综合征/红皮真菌病患者应尽早开始ECP治疗，最好在1-3线时。

摘要：

目前已证实体外光化学疗法(ECP)对Sezary综合征(SS)和真菌红皮病(MF)患者具有治疗作用。为了检验ECP在现代新型治疗方法中的有效性，Crystal Gao等人对其医院65例确诊为SS或伴有血液受累的红皮性MF患者进行了回顾性分析。研究结点是以总体存活率(OS)和下一次治疗时间(TTNT)来评估患者的预后。

诊断后的中位随访时间为48个月（范围1-225个月），预测的中位OS为120个月。大多数(88%)患者在第1-3线治疗时开始采用ECP，作为单一疗法或与其他全身药物联合使用。与以下药物相比，ECP单一疗法的TTNT明显延长：干扰素（p=0.0067）、组蛋白去乙酰化酶抑制剂（p=0.0003）、新型免疫治疗药物（p=0.0028）、低剂量甲氨蝶呤和化疗。特别是早早开始ECP治疗（第1-3线时），TTNT的时间可长达47个月。

本研究结果支持采用ECP治疗SS/红皮性MF，提示ECP应尽早被考虑用于治疗这些患者。

原始出处：

Crystal Gao， et al.Prolonged survival with the early use of a novel extracorporeal photopheresis regimen in patients with Sézary Syndrome.Blood 2019 ：blood.2019000765； doi： https：//doi.org/10.1182/blood.2019000765

本文系梅斯医学（MedSci）原创编译，转载需授权！

评论区 (8)
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    2019-10-14 wodejia-dayu

    #ECP#

    0

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    2020-07-23 tastas

    #红皮病#

    0

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    2020-07-26 bnurmamat

    #患者预后#

    0

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    2020-06-11 zhangying8788

    #真菌红皮病#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2042113, encodeId=e6dd2042113bb, content=<a href='/topic/show?id=728c65040e' target=_blank style='color:#2F92EE;'>#ECP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6504, encryptionId=728c65040e, topicName=ECP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ca4300, createdName=wodejia-dayu, createdTime=Mon Oct 14 02:23:00 CST 2019, time=2019-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003901, encodeId=bbab2003901e1, content=<a href='/topic/show?id=0a04e714467' target=_blank style='color:#2F92EE;'>#红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77144, encryptionId=0a04e714467, topicName=红皮病)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Thu Jul 23 12:23:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692070, encodeId=34bf16920e067, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sun Jul 26 01:23:00 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800664, encodeId=e3161800664b4, content=<a href='/topic/show?id=78a2e2684e3' target=_blank style='color:#2F92EE;'>#真菌红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72684, encryptionId=78a2e2684e3, topicName=真菌红皮病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Thu Jun 11 08:23:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040583, encodeId=ff1520405831c, content=<a href='/topic/show?id=70d83351235' target=_blank style='color:#2F92EE;'>#化学疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33512, encryptionId=70d83351235, topicName=化学疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Fri Mar 06 23:23:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353782, encodeId=32451353e8224, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431613, encodeId=f696143161338, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581019, encodeId=701e158101960, content=<a href='/topic/show?id=a13516191d8' target=_blank style='color:#2F92EE;'>#Sezary综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16191, encryptionId=a13516191d8, topicName=Sezary综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=336016689281, createdName=ms9608593228839890, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]
    2020-03-06 chg121

    #化学疗法#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2042113, encodeId=e6dd2042113bb, content=<a href='/topic/show?id=728c65040e' target=_blank style='color:#2F92EE;'>#ECP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6504, encryptionId=728c65040e, topicName=ECP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ca4300, createdName=wodejia-dayu, createdTime=Mon Oct 14 02:23:00 CST 2019, time=2019-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003901, encodeId=bbab2003901e1, content=<a href='/topic/show?id=0a04e714467' target=_blank style='color:#2F92EE;'>#红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77144, encryptionId=0a04e714467, topicName=红皮病)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Thu Jul 23 12:23:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692070, encodeId=34bf16920e067, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sun Jul 26 01:23:00 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800664, encodeId=e3161800664b4, content=<a href='/topic/show?id=78a2e2684e3' target=_blank style='color:#2F92EE;'>#真菌红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72684, encryptionId=78a2e2684e3, topicName=真菌红皮病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Thu Jun 11 08:23:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040583, encodeId=ff1520405831c, content=<a href='/topic/show?id=70d83351235' target=_blank style='color:#2F92EE;'>#化学疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33512, encryptionId=70d83351235, topicName=化学疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Fri Mar 06 23:23:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353782, encodeId=32451353e8224, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431613, encodeId=f696143161338, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581019, encodeId=701e158101960, content=<a href='/topic/show?id=a13516191d8' target=_blank style='color:#2F92EE;'>#Sezary综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16191, encryptionId=a13516191d8, topicName=Sezary综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=336016689281, createdName=ms9608593228839890, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]
    2019-09-04 zhaojie88

    #真菌#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2042113, encodeId=e6dd2042113bb, content=<a href='/topic/show?id=728c65040e' target=_blank style='color:#2F92EE;'>#ECP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6504, encryptionId=728c65040e, topicName=ECP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ca4300, createdName=wodejia-dayu, createdTime=Mon Oct 14 02:23:00 CST 2019, time=2019-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003901, encodeId=bbab2003901e1, content=<a href='/topic/show?id=0a04e714467' target=_blank style='color:#2F92EE;'>#红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77144, encryptionId=0a04e714467, topicName=红皮病)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Thu Jul 23 12:23:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692070, encodeId=34bf16920e067, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sun Jul 26 01:23:00 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800664, encodeId=e3161800664b4, content=<a href='/topic/show?id=78a2e2684e3' target=_blank style='color:#2F92EE;'>#真菌红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72684, encryptionId=78a2e2684e3, topicName=真菌红皮病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Thu Jun 11 08:23:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040583, encodeId=ff1520405831c, content=<a href='/topic/show?id=70d83351235' target=_blank style='color:#2F92EE;'>#化学疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33512, encryptionId=70d83351235, topicName=化学疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Fri Mar 06 23:23:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353782, encodeId=32451353e8224, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431613, encodeId=f696143161338, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581019, encodeId=701e158101960, content=<a href='/topic/show?id=a13516191d8' target=_blank style='color:#2F92EE;'>#Sezary综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16191, encryptionId=a13516191d8, topicName=Sezary综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=336016689281, createdName=ms9608593228839890, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]
    2019-09-04 zhouqu_8

    #综合征#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2042113, encodeId=e6dd2042113bb, content=<a href='/topic/show?id=728c65040e' target=_blank style='color:#2F92EE;'>#ECP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6504, encryptionId=728c65040e, topicName=ECP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ca4300, createdName=wodejia-dayu, createdTime=Mon Oct 14 02:23:00 CST 2019, time=2019-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003901, encodeId=bbab2003901e1, content=<a href='/topic/show?id=0a04e714467' target=_blank style='color:#2F92EE;'>#红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77144, encryptionId=0a04e714467, topicName=红皮病)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Thu Jul 23 12:23:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692070, encodeId=34bf16920e067, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sun Jul 26 01:23:00 CST 2020, time=2020-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800664, encodeId=e3161800664b4, content=<a href='/topic/show?id=78a2e2684e3' target=_blank style='color:#2F92EE;'>#真菌红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72684, encryptionId=78a2e2684e3, topicName=真菌红皮病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68b666, createdName=zhangying8788, createdTime=Thu Jun 11 08:23:00 CST 2020, time=2020-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040583, encodeId=ff1520405831c, content=<a href='/topic/show?id=70d83351235' target=_blank style='color:#2F92EE;'>#化学疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33512, encryptionId=70d83351235, topicName=化学疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Fri Mar 06 23:23:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353782, encodeId=32451353e8224, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431613, encodeId=f696143161338, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581019, encodeId=701e158101960, content=<a href='/topic/show?id=a13516191d8' target=_blank style='color:#2F92EE;'>#Sezary综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16191, encryptionId=a13516191d8, topicName=Sezary综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=336016689281, createdName=ms9608593228839890, createdTime=Wed Sep 04 13:23:00 CST 2019, time=2019-09-04, status=1, ipAttribution=)]
    2019-09-04 ms9608593228839890

    #Sezary综合征#

    0