心血管

订阅

MedSci主页 / 所有栏目 / 心血管

Am J Clin Nutr:B族维生素或n-3脂肪酸不能改善心脏病幸存者抑郁

2012-08-01 不详 网络

B族维生素n-3脂肪酸心脏病幸存者抑郁
关注

SU.FOL.OM3(补充叶酸、维生素B-6和B-12和/或ω-3脂肪酸试验)是一项二级预防试验，于2003~2009年间纳入2,501例年龄45~80岁的受试者。将受试者随机分组，给予5-甲基四氢叶酸(0.56 mg)、维生素B6(3 mg)和B12(0.02 mg)；以2:1比例给予EPA和DHA(600 mg)；给予B族维生素和n-3脂肪酸；或给予安慰剂。在第3年和第5年时用GDS老年抑郁量

SU.FOL.OM3(补充叶酸、维生素B-6和B-12和/或ω-3脂肪酸试验)是一项二级预防试验，于2003~2009年间纳入2,501例年龄45~80岁的受试者。将受试者随机分组，给予5-甲基四氢叶酸(0.56 mg)、维生素B6(3 mg)和B12(0.02 mg)；以2:1比例给予EPA和DHA(600 mg)；给予B族维生素和n-3脂肪酸；或给予安慰剂。在第3年和第5年时用GDS老年抑郁量表评估抑郁症状。

结果显示，经过中位时间4.7年的干预，补充B族维生素与抑郁症状无关。然而，男性补充n-3脂肪酸与抑郁症状(GDS＞10)呈正相关(校正OR值，1.28; 95%CI，1.03~1.61)，女性中则不存在这种效应

研究者总结认为，长期、小剂量补充B族维生素或n-3脂肪酸对心血管疾病幸存者的抑郁症状没有益处。n-3脂肪酸对男性健康似有不良影响。

评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1778732, encodeId=8d851e7873229, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Wed Oct 17 07:01:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779108, encodeId=351c1e791085c, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Feb 09 13:01:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605335, encodeId=d732160533596, content=<a href='/topic/show?id=81103828b7' target=_blank style='color:#2F92EE;'>#B族维生素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3828, encryptionId=81103828b7, topicName=B族维生素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=497b19379272, createdName=ms1692212821629096, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
    2012-10-17 mhzhuang@stu.e

    #3脂肪酸#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1778732, encodeId=8d851e7873229, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Wed Oct 17 07:01:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779108, encodeId=351c1e791085c, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Feb 09 13:01:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605335, encodeId=d732160533596, content=<a href='/topic/show?id=81103828b7' target=_blank style='color:#2F92EE;'>#B族维生素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3828, encryptionId=81103828b7, topicName=B族维生素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=497b19379272, createdName=ms1692212821629096, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
    2013-02-09 mhzhuang@stu.e

    #3脂肪酸#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1778732, encodeId=8d851e7873229, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Wed Oct 17 07:01:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779108, encodeId=351c1e791085c, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Feb 09 13:01:00 CST 2013, time=2013-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605335, encodeId=d732160533596, content=<a href='/topic/show?id=81103828b7' target=_blank style='color:#2F92EE;'>#B族维生素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3828, encryptionId=81103828b7, topicName=B族维生素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=497b19379272, createdName=ms1692212821629096, createdTime=Fri Aug 03 02:01:00 CST 2012, time=2012-08-03, status=1, ipAttribution=)]
    2012-08-03 ms1692212821629096

    #B族维生素#

    0