BMC Endocr Disord:老年2型糖尿病患者骨折的风险增加

2020-03-04 不详 网络

2型糖尿病(T2DM)的老年患者比无糖尿病的老年患者更容易发生骨折。需要住院治疗的骨折极大地影响了生活质量,尽管老年T2DM患者具有多种与骨折相关的危险因素,但只有少数研究对亚洲人群进行了详细评估。我们对老年T2DM患者进行了回顾性研究,以评估与骨折风险相关的因素。我们对电子病历(EMR)进行了一项回顾性研究,纳入日本东京中部一家公共综合医学机构收治的T2DM≥65岁的患者。评估了与骨折相关的因素

2型糖尿病(T2DM)的老年患者比无糖尿病的老年患者更容易发生骨折。需要住院治疗的骨折极大地影响了生活质量,尽管老年T2DM患者具有多种与骨折相关的危险因素,但只有少数研究对亚洲人群进行了详细评估。我们对老年T2DM患者进行了回顾性研究,以评估与骨折风险相关的因素。

我们对电子病历(EMR)进行了一项回顾性研究,纳入日本东京中部一家公共综合医学机构收治的T2DM≥65岁的患者。评估了与骨折相关的因素,这些骨折需要对具有T2DM特征和使用降糖药的老年患者进行住院治疗。使用多因素逻辑回归分析确定与骨折风险相关的因素。

结果共分析了2112例T2DM的老年患者(年龄≥65岁)。其中,有69名(3.3%)患者因骨折而住院。与骨折相关的因素是女性(OR,3.46),eGFR <60ml/min /1.73μm2(OR,0.55)和噻唑烷的使用(OR,4.28)。此外,基于性别的另一项分析显示,噻唑烷类药物的使用与两性骨折风险密切相关。

总之,该研究结果表明,在老年T2DM患者中,与骨折相关的关键因素是男性和女性均使用噻唑烷。在这项研究中,新发现使用噻唑烷是增加老年男性需要住院的骨折风险的因素。当选择降糖药治疗老年T2DM患者时,应考虑研究结果。信息偏倚,选择偏倚以及伴随药物的作用可能是eGFR <60 mL/min/1.73 m2降低骨折风险的根本原因。但是,细节未知,需要进一步调查。

原始出处:

Takeshi Horii, Makiko Iwasawa, et al., Investigating the risk of bone fractures in elderly patients with type 2 diabetes mellitus: a retrospective study. BMC Endocr Disord. 2019; 19: 81. doi: 10.1186/s12902-019-0413-0

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    2020-07-13 cmj8wellington

    #Dis#

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    2020-07-24 ms3025846204744509

    #BMC#

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    2020-05-09 cmsvly

    #Disord#

    0

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    2020-03-06 aids213
  6. [GetPortalCommentsPageByObjectIdResponse(id=1976330, encodeId=351219e633053, content=<a href='/topic/show?id=1bc680101d7' target=_blank style='color:#2F92EE;'>#老年2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80101, encryptionId=1bc680101d7, topicName=老年2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Thu Oct 29 14:46:00 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013202, encodeId=203e201320241, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Jul 13 13:46:00 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975005, encodeId=2d3119e5005a4, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Fri Jul 24 10:46:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784418, encodeId=fc261e844181c, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Sat May 09 18:46:00 CST 2020, time=2020-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383613, encodeId=cb4a13836134e, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 06 12:46:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474892, encodeId=393214e489234, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 06 12:46:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380116, encodeId=adc3380116aa, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Thu Mar 05 22:53:06 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042997, encodeId=d2a5104299e9d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 05 00:46:00 CST 2020, time=2020-03-05, status=1, ipAttribution=)]
    2020-03-06 xue8604
  7. [GetPortalCommentsPageByObjectIdResponse(id=1976330, encodeId=351219e633053, content=<a href='/topic/show?id=1bc680101d7' target=_blank style='color:#2F92EE;'>#老年2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80101, encryptionId=1bc680101d7, topicName=老年2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Thu Oct 29 14:46:00 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013202, encodeId=203e201320241, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Jul 13 13:46:00 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975005, encodeId=2d3119e5005a4, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Fri Jul 24 10:46:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784418, encodeId=fc261e844181c, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Sat May 09 18:46:00 CST 2020, time=2020-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383613, encodeId=cb4a13836134e, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Mar 06 12:46:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474892, encodeId=393214e489234, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Mar 06 12:46:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380116, encodeId=adc3380116aa, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Thu Mar 05 22:53:06 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042997, encodeId=d2a5104299e9d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 05 00:46:00 CST 2020, time=2020-03-05, status=1, ipAttribution=)]
    2020-03-05 qingfengqishi5

    学习了,学习了

    0

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    2020-03-05 misszhang

    谢谢MedSci提供最新的资讯

    0