Hypertension:脉压或为老年人群弱危险因素

2013-12-17 佚名 医学论坛网

中欧一项研究表明,在年龄<60岁的患者中,动态脉压不增加危险分层;在老年人群中脉压为弱危险因素,并且在低于64 mmHg时可能无害。论文12月9日在线发表于《高血压》(Hypertension)。 此项研究共纳入9938例受试者,其中47.3%为女性。进行年龄分层(<60和≥60岁)并以平均风险作为参照后,通过脉压十分位分布或脉压逐级升高(+ 1 mmHg)相关

中欧一项研究表明,在年龄<60岁的患者中,动态脉压不增加危险分层;在老年人群中脉压为弱危险因素,并且在低于64 mmHg时可能无害。论文12月9日在线发表于《高血压》(Hypertension)。【原文下载】

此项研究共纳入9938例受试者,其中47.3%为女性。进行年龄分层(<60和≥60岁)并以平均风险作为参照后,通过脉压十分位分布或脉压逐级升高(+ 1 mmHg)相关风险计算多变量校正危险比(HR)。所有校正均包括平均动脉压。

结果显示,在6028例较年轻受试者中,心血管事件(HR 1.58)和心脏性事件(HR 1.52)风险仅在脉压最高十分位时升高(平均60.6 mmHg)。在3910例老年受试者中,风险在脉压最高十分位时升高(平均76.1 mmHg);总体和心血管死亡HR分别为1.30和1.62,心血管、心源性和脑血管事件HR分别为1.52、1.69和1.40。在老年受试者中,脉压最高十分位对总体风险的促成度不足0.3%。

原文出处:

Gu YM, Thijs L, Li Y, Asayama K, Boggia J, Hansen TW, Liu YP, Ohkubo T, Björklund-Bodegård K, Jeppesen J, Dolan E, Torp-Pedersen C, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Mena LJ, Wang J, O'Brien E, Verhamme P, Filipovsky J, Maestre GE, Staessen JA; on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular. Outcomes (IDACO) Investigators.Outcome-Driven Thresholds for Ambulatory Pulse Pressure in 9938 Participants Recruited From 11 Populations.Hypertension. 2013 Dec 9. 【原文下载】

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    2014-09-24 feather89
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