Biofouling:松油烯-4-醇和香芹酚可显著减少口腔生物膜的细菌量

2019-07-28 不详 网络

本研究旨在研究松油烯-4-醇(T4ol)和香芹酚对单种和多种生物膜的细胞毒活性和抑制作用。 在口腔角质形成细胞上测试每种化合物的毒性,并通过XTT测定评估。通过结晶紫测定分析单种生物膜的抑制和根除,并通过qPCR评估对多物种生物膜组成的影响。 结果显示,与氯己定相比,T4ol和香芹酚不影响上皮细胞活力,氯己定显示出高细胞毒性作用。使用T4ol和香芹酚处理可抑制和根除单一生物膜。对于多物种生物膜,尤

本研究旨在研究松油烯-4-醇(T4ol)和香芹酚对单种和多种生物膜的细胞毒活性和抑制作用。

在口腔角质形成细胞上测试每种化合物的毒性,并通过XTT测定评估。通过结晶紫测定分析单种生物膜的抑制和根除,并通过qPCR评估对多物种生物膜组成的影响。

结果显示,与氯己定相比,T4ol和香芹酚不影响上皮细胞活力,氯己定显示出高细胞毒性作用。使用T4ol和香芹酚处理可抑制和根除单一生物膜。对于多物种生物膜,尤其是对牙周病原体,观察到相同的抑制作用。

总之,该研究结果表明,特定浓度的T4ol和香芹酚对上皮细胞无毒性,减少了单种和多种生物膜中牙周病原体的数量。

原始出处:

Maquera Huacho PM, Rodriguez Herrero E, et al., Terpinen-4-ol and carvacrol affect multi-species biofilm composition. Biofouling. 2019 Jul 8:1-12. doi: 10.1080/08927014.2019.1630386.

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    2019-10-29 sunylz
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    2020-02-21 weiz