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Adv Healthc Mater：抗菌肽/GO完美解决耐药细菌

2019-09-08 不详 网络

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抗菌肽（AMPs）有望从根本上解决耐药细菌的破坏性威胁。然而，AMP的缺点（例如，细胞膜穿透效率差）严重阻碍了其临床应用。本研究中，研究人员实现了蜂毒肽（作为代表性AMP）和石墨烯或氧化石墨烯（Gra或GO）纳米片的混合复合物的合理设计，以增强抗菌能力。检测显示，与原始蜂毒肽相比，特异设计的AMP-Gra（/ GO）复合物在跨膜穿孔中的效率显著提高，肽的阈值工作浓度降低了十倍以上；此外，它对革兰氏

抗菌肽（AMPs）有望从根本上解决耐药细菌的破坏性威胁。然而，AMP的缺点（例如，细胞膜穿透效率差）严重阻碍了其临床应用。本研究中，研究人员实现了蜂毒肽（作为代表性AMP）和石墨烯或氧化石墨烯（Gra或GO）纳米片的混合复合物的合理设计，以增强抗菌能力。

检测显示，与原始蜂毒肽相比，特异设计的AMP-Gra（/ GO）复合物在跨膜穿孔中的效率显著提高，肽的阈值工作浓度降低了十倍以上；此外，它对革兰氏阴性和革兰氏阳性细菌的抗菌活性提高了20倍。这种改善归因于纳米片和蜂毒肽的协同插入，因为它们之间的抗菌机制相似，并且进一步受复合物的结构因素的调节，包括片间距和Gra /GO片的表面功能化等。

总之，这些结果为使用纳米技术设计AMP以提高抗菌性能提供了实用指南，特别是基于Gra/GO纳米片的靶向功能化。

原始出处：

Lu X, Liu J, et al., Designing Melittin-Graphene Hybrid Complexes for Enhanced Antibacterial Activity. Adv Healthc Mater. 2019 May;8(9):e1801521. doi: 10.1002/adhm.201801521. Epub 2019 Mar 13.

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    2020-08-12 shizhenshan

    #ALT#

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    2020-06-22 lingqf

    #耐药细菌#

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    2019-09-10 ms7899726347904398

    #抗菌#

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    2019-09-10 yyanpro@28cn.c

    #Health#

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