NEJM:病例——播散性隐球菌病

2014-05-07 MedSci MedSci原创

本月1日,在NEJM上发表了播散性隐球菌病例一则,以下为翻译: 患者,男,60岁,进行性皮损4周。患者因患有慢性淋巴细胞白血病(CLL),在过去的6年里,连续接受利妥昔单抗+氟达拉滨+环磷酰胺,阿仑单抗+地塞米松,利妥昔单抗+苯达莫司汀+甲基强的松龙等联合治疗,化疗后获部分缓解。血检:血CD4+T细胞计数为每立方毫米20个(1%)体格检查发现:患者面部、肩膀,手臂,和腿处有多个大小不

本月1日,在NEJM上发表了播散性隐球菌病例一则,以下为翻译:



患者,男,60岁,进行性皮损4周。

患者因患有慢性淋巴细胞白血病(CLL),在过去的6年里,连续接受利妥昔单抗+氟达拉滨+环磷酰胺,阿仑单抗+地塞米松,利妥昔单抗+苯达莫司汀+甲基强的松龙等联合治疗,化疗后获部分缓解。

血检:血CD4+T细胞计数为每立方毫米20个(1%)

体格检查发现:患者面部、肩膀,手臂,和腿处有多个大小不等的脐形丘疹(上图AB)。同时有慢性淋巴细胞白血病相关的多腺病。无一般健康状况下降,神经系统症状(如头痛),精神状态改变,颈部僵硬等症状,尤其是无发热。

疹活检发现大量隐球酵母(C图,箭头所示;HE染色)。脑脊液,血液,尿液和皮肤中培养出新型隐球菌,血清隐球菌抗原检测阳性,滴度为1:400。两性霉素B联合氟胞嘧啶治疗3周后转为氟康唑治疗。皮损逐渐消失,血清隐球菌抗原滴度降低。

原始出处:

Lindsey R. Baden.Disseminated Cryptococcosis.The new england journal o f medicine may 1, 2014

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