Obstet Gynecol:妊娠初期血清脂肪酸结合蛋白4与妊娠糖尿病之间的相关性分析!

2017-10-27 xing.T MedSci原创

由此可见,妊娠初期访视中较高的脂肪酸结合蛋白4浓度与GDM风险增加有关,这可能有助于确定有较高GDM风险的个体,以进行早期预防策略。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一篇研究文章,研究人员旨在评估妊娠初期血浆中测量的脂肪酸结合蛋白4浓度是否与妊娠期糖尿病(GDM)相关。

在2015年7月至2016年6月期间,研究人员在中国两个城市(哈尔滨和北京)的三个产科中心进行了这项前瞻性多中心队列研究。研究人员收集并分析了受试者妊娠初期空腹血糖和脂肪酸结合蛋白4浓度以及在妊娠24至28周之间进行75g口服葡萄糖耐量试验的GDM筛选数据。

1150名孕妇血浆数据可用,其中135例(11.7%)孕妇发生GDM。GDM孕妇的脂肪酸结合蛋白4四分位数分布范围从3.8%(第一四分位数)至21.6%(第四四分位数)。在多变量模型中,将脂肪酸结合蛋白4第二四分位数,第三四分位数和第四四分位数与的第一四分位数进行比较,研究人员发现脂肪酸结合蛋白4浓度位于第二四分位数,第三四分位数和第四四分位数范围与GDM发生发展相关,各自相关的调整后比值比(95%可信区间)为1.76(1.21-2.58),2.36(1.55-4.29)和3.57(1.99-6.11)。研究人员观察到单独已知的危险因素和增加脂肪酸结合蛋白4浓度之间的受试者工作特征曲线下面积存在显著的差异(差异为0.042 [95%可信区间为0.028-0.055]; P=0.03)。

由此可见,妊娠初期访视中较高的脂肪酸结合蛋白4浓度与GDM风险增加有关,这可能有助于确定有较高GDM风险的个体,以进行早期预防策略。

原始出处:

Tu, Wen-Jun, et al. First-Trimester Serum Fatty Acid-Binding Protein 4 and Subsequent Gestational Diabetes Mellitus.Obstetrics & Gynecology.2017.http://journals.lww.com/greenjournal/Abstract/2017/11000/First_Trimester_Serum_Fatty_Acid_Binding_Protein_4.11.aspx

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2018-06-24 shenxlcyp

    #相关性#

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    2018-07-16 yhy100200

    #TET#

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    2017-10-27 131****1460

    学习了受益匪浅

    0

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    2017-10-27 thlabcde

    好资料学习了!

    0

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