J CEREBR BLOOD F MET:运动起来吧! 间歇性冲刺训练改变大脑糖代谢

2017-10-28 海北 MedSci原创

已有的研究表明,大脑胰岛素刺激的葡萄糖摄取(GU)在肥胖和胰岛素抵抗受试者中增加,但在体重减轻后能够恢复正常,同时全身胰岛素敏感性也会有所改善。

已有的研究表明,大脑胰岛素刺激的葡萄糖摄取(GU)在肥胖和胰岛素抵抗受试者中增加,但在体重减轻后能够恢复正常,同时全身胰岛素敏感性也会有所改善。

来自芬兰图尔库大学的研究人员探究了短期运动训练(中等强度连续训练(MICT)或间歇性冲刺训练SIT))是否改变胰岛素抵抗人群脑能量代谢的底物。

研究人员招募了患有胰岛素抵抗的患者(n = 21,BMI 23.7-34.3 kg / m2,年龄43-55岁),随机分为MICT(n = 11,VO2峰值≥60%)或SIT(n = 10,力竭)组,并进行了为期两周的运动干预。研究人员使用PET测量胰岛素刺激期间的脑葡萄糖摄取和空腹时的游离脂肪酸摄取(FAU)。

研究人员发现,在基线时,脑葡萄糖摄取与空腹胰岛素水平呈正相关,与全身胰岛素敏感性呈负相关。两种训练模式都能导致全身胰岛素敏感性有所提高(20%,p = 0.007),但是只有SIT导致有氧代谢能力增加(5%,p = 0.03)。SIT还能够在皮质灰质(12%,p = 0.03)和特定脑区(p <0.05,除了枕叶皮质以外的所有区域)中降低了胰岛素刺激的脑葡萄糖摄取,而在MICT组未观察到变化。两组受试者训练后大脑FAU均保持不变。

这些研究结果表明,短期SIT能够有效降低久坐不动的胰岛素抵抗受试者胰岛素刺激的脑葡萄糖摄取。


原始出处:

Sanna M Honkala et al. Short-term interval training alters brain glucose metabolism in subjects with insulin resistanceJournal of Cerebral Blood Flow & Metabolism, 2017; 0271678X1773499 DOI: 10.1177/0271678X17734998


本文系梅斯医学(MedSci)原创编译整理,转载需授权


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    2018-06-24 一闲
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    2017-10-30 186****0580(小山羊)

    学习了谢谢了

    0

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    2017-10-30 zz70
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    2017-10-29 Y—xianghai

    学习了新知识

    0

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