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循环肿瘤DNA预测Palbociclib（帕博昔布）在乳腺癌患者中的有效性

2018-03-04 MedSci MedSci原创

帕博昔布palbociclib循环肿瘤DNA
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一项最新研究发现，循环肿瘤DNA的血液检测可以预测女性患者对乳腺癌新药Palbociclib是否有反应，这比现有检测方法提早了数月。伦敦癌症研究所的科学家们表示，该血液检测方法可以在两到三周内检测到该药物是否有效。

一项最新研究发现，循环肿瘤DNA的血液检测可以预测女性患者对乳腺癌新药Palbociclib是否有反应，这比现有检测方法提早了数月。伦敦癌症研究所的科学家们表示，该血液检测方法可以在两到三周内检测到该药物是否有效。

研究人员测试了雌激素受体阳性乳腺癌患者，这些患者参与了Palbociclib治疗晚期乳腺癌的临床试验。目前，女性患者必须等待两到三个月才能通过扫描发现Palbociclib是否有效，而新的血液检测方法则着眼于寻找循环肿瘤DNA（进入血液的脱落的肿瘤细胞DNA片段），通过这些样本研究人员可以检测到与癌症相关的DNA突变。

研究人员发现，他们可以通过比较在治疗开始前和开始后15天的血液中PIK3CA基因的量来预测Palbociclib的治疗是否可行。在该研究中，73名女性患者存在PIK3CA突变并且进行了血液检查，开始治疗后，其中52人接受了Palbociclib治疗。在这些女性中，那些15天内PIK3CA循环DNA小幅下降的患者的中位无进展生存期仅为4.1个月，而PIK3CA循环DNA大幅下降的女性患者的中位无进展生存期为11.2个月。

原始出处：

https://www.europeanpharmaceuticalreview.com/news/73189/blood-test-palbociclib-breast-cancer/

本文系梅斯医学（MedSci）原创编译整理，转载需授权!

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    2018-03-06 ysjykql

    #palbociclib#

    0

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    2018-03-06 ms1948154235210413

    #循环肿瘤DNA#

    0

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    2018-03-06 hanhaisha2013

    #乳腺癌患者#

    0