AJOG:囊胚期胚胎移植术后妊娠结局

2016-03-16 Mechront 译 MedSci原创

研究者进行了一项基于人群的回顾性研究,比较囊胚期胚胎移植(5-6天)、卵裂时期胚胎转移(2-3)和自然受孕情况下的母胎结局。其中囊胚期胚胎移植组有4819例单胎,卵裂时期胚胎转移组有25,747例单胎,自然受孕组该数据为1,196,394。囊胚期胚胎移植组的单胎分别与卵裂时期胚胎转移组和自然受孕组比较,出生缺陷风险并没有增加(调整后比值比分别为:AOR, 0.94; 95% CI, 0.79-1.

研究者进行了一项基于人群的回顾性研究,比较囊胚期胚胎移植(5-6天)、卵裂时期胚胎转移(2-3)和自然受孕情况下的母胎结局。其中囊胚期胚胎移植组有4819例单胎,卵裂时期胚胎转移组有25,747例单胎,自然受孕组该数据为1,196,394。

囊胚期胚胎移植组的单胎分别与卵裂时期胚胎转移组和自然受孕组比较,出生缺陷风险并没有增加(调整后比值比分别为:AOR, 0.94; 95% CI, 0.79-1.13、AOR, 1.61; 95% CI, 1.14-2.29)。不过囊胚期胚胎移植组的单胎与自然受孕组相比,早产风险更高(AOR, 1.17; 95% CI, 1.05-1.31)。囊胚期胚胎移植组的单胎与卵裂时期胚胎转移组相比,低出生体重儿发生率更低(AOR, 0.83; 95% CI, 0.71-0.97)。囊胚期胚胎移植组的单胎分别与卵裂时期胚胎转移组和自然受孕组比较,小于胎龄儿发生率更低(AOR, 0.71; 95% CI, 0.56-0.88、AOR, 0.70; 95% CI, 0.57-0.87)。囊胚期胚胎移植组发生前置胎盘和胎盘早剥风险比卵裂时期胚胎转移组更高(AOR, 2.08; 95% CI, 1.70-2.55、AOR, 1.62; 95% CI, 1.15-2.29),与自然受孕组相比,风险也更高(AOR, 6.38; 95% CI, 5.31-7.66 、AOR, 2.31; 95% CI, 1.70-3.13)。

研究结果表明,囊胚期胚胎移植不会增加胎儿出生缺陷风险,不过围生期死亡率和胎盘并发症风险会更高,以后还需要更多的调查和研究来验证该结果。

原始出处:

Ginström Ernstad E, Bergh C,et al.Neonatal and maternal outcome after blastocyst transfer: a population-based registry study.Am J Obstet Gynecol. 2016 Mar;214(3):378.e1-378.e10.


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    2016-07-07 cy0324
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