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Stroke：证实脑微血管损伤与脑血管周围间隙扩大有关

2016-04-01 MedSci MedSci原创

微血管损伤脑血管周围间隙扩张视网膜血管

脑血管周围间隙扩大是公认的脑微血管损伤的影像学标记，但这两者之间的关系还未通过直接可视化的小血管来证实。我们调查了视网膜成像的微血管口径和大脑MRI血管周围间隙扩大（ePVSs)的关系。

脑血管周围间隙扩大是公认的脑微血管损伤的影像学标记，但这两者之间的关系还未通过直接可视化的小血管来证实。我们调查了视网膜成像的微血管口径和大脑MRI血管周围间隙扩大（ePVSs)的关系。

包含来自Rotterdam研究的704名受试者。通过半自动照相对视网膜眼底小动脉和小静脉进行测量。

在眼底视网膜小动脉和小静脉的管径测量半自动地照片。使用标准化的评级方法，计算半卵圆中心、基底神经节,海马体,中脑的ePVSs。使用负二项回归模型决定视网膜微血管口径与ePVSs的关系，校正年龄、性别、血管口径,大脑结构MRI标记和心血管危险因素。

结果发现，较窄的动脉和较宽的静脉口径与半卵圆中心和海马区域更多的ePVSs相关。半卵圆中心和海马体区动脉比值比（95%CI）是1.07 (1.01-1.14) 和1.13 (1.04-1.22),静脉分别是1.08 (1.01-1.16) 和1.09 (1.00-1.18)。这些联系独立于其他的脑MRI标志物和心血管风险因素。

结论：视网膜微血管口径与ePVSs相关，证实了微血管损伤与ePVSs相关的假说。

原市场处：

Mutlu U1, Adams HH1, Hofman A1, van der Lugt A1, et al,Retinal Microvascular Calibers Are Associated with Enlarged Perivascular Spaces in the Brain. Stroke. 2016 Mar 15. pii: STROKEAHA.115.012438. [Epub ahead of print]

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    2016-08-05 bbwuyu_013

    #血管损伤#

    0

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    2016-04-03 mgqwxj

    #微血管#

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    2016-04-03 智者为医08

    #损伤#

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