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SCI REP：为什么你冬天容易长胖？

2018-01-11 海北 MedSci原创

脂肪光照
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皮下白色脂肪组织（scWAT）是人类主要的脂肪库，并且它也是调节全身代谢的中心参与者。暴露于阳光中的紫外线是皮肤合成维生素D和产生色素沉着所必须的，而穿透皮肤的较长的可见波长可能可以调节皮下白色脂肪组织的功能。

皮下白色脂肪组织（scWAT）是人类主要的脂肪库，并且它也是调节全身代谢的中心参与者。暴露于阳光中的紫外线是皮肤合成维生素D和产生色素沉着所必须的，而穿透皮肤的较长的可见波长可能可以调节皮下白色脂肪组织的功能。

近日，来自阿尔伯塔大学的研究人员在人类皮下白色脂肪组织中发现了一种新型的蓝色光敏电流，其由黑素蛋白（melanopsin）与瞬时受体电位典型阳离子通道偶联介导。在阳光明媚的日子，该通路能够在生理强度下被穿透皮肤的光所激活。分化的脂肪细胞每日暴露于蓝光下，会导致内部脂滴尺寸减小，脂分解的基底速率增加，以及脂连蛋白和瘦素分泌改变。

因此，研究人员的研究结果表明，皮下白色脂肪组织的功能可能直接受环境日光照射的影响，并且这可能对我们目前对脂肪细胞生物学的理解具有重要意义。

原始出处：

Katarina Ondrusova et al. Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axis. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16689-4

本文系梅斯医学（MedSci）原创编译整理，转载需授权! 

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    2018-01-14 天涯183

    非常好的文章.学习了

    0

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    2018-01-12 haige

    学习了，谢谢！

    0

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    2018-01-12 186****0580(小山羊）

    学习了谢谢了

    0

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    2018-01-12 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jan 11 19:27:11 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277549, encodeId=58cc2e7549f3, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu Jan 11 17:00:41 CST 2018, time=2018-01-11, status=1, ipAttribution=), 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    2018-01-12 jihuaijun1112

    学习学习学习

    0

  6. 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    2018-01-11 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jan 11 20:57:45 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277582, encodeId=ff082e758272, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jan 11 20:00:57 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277578, encodeId=f5192e75780a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jan 11 19:27:11 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277549, encodeId=58cc2e7549f3, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu Jan 11 17:00:41 CST 2018, time=2018-01-11, status=1, ipAttribution=), 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    2018-01-11 虈亣靌

    学习一下谢谢分享

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jan 11 19:27:11 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277549, encodeId=58cc2e7549f3, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu Jan 11 17:00:41 CST 2018, time=2018-01-11, status=1, ipAttribution=), 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    2018-01-11 131****1460

    学习了受益匪浅

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Thu Jan 11 19:27:11 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277549, encodeId=58cc2e7549f3, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu Jan 11 17:00:41 CST 2018, time=2018-01-11, status=1, ipAttribution=), 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    2018-01-11 三生有幸9135

    学习一下谢谢分享

    0

  10. 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    2018-01-11 1e0f8808m18(暂无匿称)

    肥胖的季节性原因.

    0

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