J Orthop Surg Res:评估细胞辅助脂肪移植和常规脂肪移植的临床疗效

2019-01-12 MedSci MedSci原创

细胞辅助脂肪移植是一种新的脂肪移植技术。本研究旨在探讨细胞辅助脂肪移植技术与传统脂肪移植相比的临床疗效。根据PRISMA指南,系统地搜索了PubMed,Embase和Cochrane图书馆的相关文章。检索了关注单独脂肪移植与细胞辅助脂肪移植的脂肪存活率和/或患者满意率的研究。汇总估计的脂肪存活率和患者满意率。根据移植部位分层进行亚组分析。计算文章偏倚。此外,通过灵敏度分析评估结果的稳定性。结果显示

细胞辅助脂肪移植是一种新的脂肪移植技术。本研究旨在探讨细胞辅助脂肪移植技术与传统脂肪移植相比的临床疗效。

根据PRISMA指南,系统地搜索了PubMed,Embase和Cochrane图书馆的相关文章。检索了关注单独脂肪移植与细胞辅助脂肪移植的脂肪存活率和/或患者满意率的研究。汇总估计的脂肪存活率和患者满意率。根据移植部位分层进行亚组分析。计算文章偏倚。此外,通过灵敏度分析评估结果的稳定性。

结果显示,荟萃分析中包含9篇文章。在个体研究中观察到脂肪存活率评估显著异质性(I 2 = 98.3%,P <0.001)。细胞辅助脂肪移植组的脂肪存活率显著高于对照组[加权平均差= 25.85,95%置信区间5.39-46.31; P = 0.013]。值得注意的是,灵敏度分析中的结果保持不变。细胞辅助脂肪移植组与对照组患者满意率无显著差异[优势比= 3.69,95%置信区间0.73-18.53; P = 0.113]。在亚组分析中,与对照组相比,患者对面部(优势比= 18.85,95%置信区间9.03,28.68; P <0.001)和手臂(优势比= 64.60,95%置信区间58.79,70.41; P <0.001)细胞辅助脂肪移植脂肪移植组的满意率明显提高)。最后,各研究没有明显的偏倚(P = 0.371)。

总之,该研究表明细胞辅助脂肪移植优于常规的脂质注射,并且脂肪存活率提高。但是,应在进一步的研究中评估长期疗效。

原始出处:

Wang Y, Wu Y. Assessment of the clinical efficacy of cell-assisted lipotransfer and conventional fat graft: a meta-analysis based on case-control studies. J Orthop Surg Res. 2017 Oct 19;12(1):155. doi: 10.1186/s13018-017-0645-5.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1907186, encodeId=96d8190e186ee, content=<a href='/topic/show?id=acc02289e40' target=_blank style='color:#2F92EE;'>#临床疗效#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22897, encryptionId=acc02289e40, topicName=临床疗效)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8346212, createdName=respect, createdTime=Mon Aug 12 15:29:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358255, encodeId=3b173582554d, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Jan 15 23:18:21 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358114, encodeId=b4923581140e, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 14 09:51:13 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032040, encodeId=89621032040de, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Jan 13 01:29:00 CST 2019, time=2019-01-13, status=1, ipAttribution=)]
    2019-01-15 清风拂面

    谢谢分享学习

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    2019-01-14 1209e435m98(暂无昵称)

    学习了,谢谢分享

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    2019-01-13 内科新手

    谢谢梅斯提供这么好的信息,学到很多

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