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Molecular Metabolism：祖父肥胖的儿孙更易受垃圾食品影响

2016-07-20 徐徐 中国科学报

肥胖垃圾食品

一项

一项在小鼠身上开展的研究表明，肥胖雄性小鼠的“孙子”更容易遭受垃圾食品带来的有害健康影响。相关成果日前发表于《分子新陈代谢》杂志。

此项发现进一步证明，新的性状无须被永久记录在家庭基因中，便可在家族中传递下去。这种现象被称为表观遗传的隔代效应。

去年，一项研究发现，肥胖男性精子中的DNA在数百个位置被修改。同时，这些精子还含有短片段RNA。这些是表观遗传修饰，即它们不影响基因的精确编码，但可能影响特定基因的活性。

如今，来自澳大利亚悉尼张任谦心脏研究所的Catherine Suter及其团队研究了父亲肥胖产生的更长期影响。为此，他们将肥胖的雄性小鼠同瘦小的雌性小鼠交配。

研究发现，当被喂食垃圾食品时，同瘦小的雄性小鼠的后代相比，肥胖雄性小鼠的“儿子”和“孙子”都更有可能表现出脂肪肝疾病和糖尿病的早期迹象。相同的效应未在“女儿”或“孙女”身上看到。

即便是肥胖雄性小鼠的“儿子”被喂以健康饮食并且保持正常体重，它们的“儿子”在接触垃圾食品后，仍有更大的倾向患上同肥胖相关的疾病。不过，这种影响似乎不会传给“曾孙”。“这是好消息，因为它表明，肥胖循环能被打破。”Suter表示。

原始出处

Jennifer E. Cropley1, 2, , 8, , Sally A. Eaton1, 2, 8, Alastair Aiken1, Paul E. Young1, Eleni Giannoulatou1, Joshua W.K. Ho1, 2, Michael E. Buckland3, Simon P. Keam4, Gyorgy Hutvagner4, David T. Humphreys1, Katherine G. Langley5, Darren C. Henstridge5, David I.K. Martin1, 6, Mark A. Febbraio7, Catherine M. Suter1.Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity.Molecular Metabolism.2016

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    2016-09-11 guojianrong

    #Meta#

    0

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    2016-09-13 维他命

    #垃圾食品#

    0

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    2016-09-20 1e10c84am36(暂无匿称)

    文章很好，非常有益

    0

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    2016-09-13 舒心和人

    看来祖上的影响还是很深远的，感谢分享

    0

  5. 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    2017-04-10 一闲

    #MET#

    0

  6. 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    2016-07-22 1249859em43(暂无昵称)

    #Metabolism#

    0

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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zGdN1x8J6HqtUI2Gpibk3sfIIBhZchAhjoiaCQlficdtQTnEqYncy3GVEMPIOJwD7t0mO2KfYGMgkIg/0, createdBy=86081727811, createdName=4546wk, createdTime=Thu Jul 21 00:37:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93814, encodeId=ec589381480, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93815, encodeId=7dca938153b, content=继续关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-22 闆锋旦

    #ABO#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1887547, encodeId=8f1e188e54754, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Sep 11 16:21:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668386, encodeId=65fa16683863d, content=<a href='/topic/show?id=652641533df' target=_blank style='color:#2F92EE;'>#垃圾食品#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41533, encryptionId=652641533df, topicName=垃圾食品)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a52126287661, createdName=维他命, createdTime=Tue Sep 13 13:21:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131803, encodeId=4a95131803d7, content=文章很好，非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:38:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125627, encodeId=73ff12562eb8, content=看来祖上的影响还是很深远的，感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zGdN1x8J6HqtUI2Gpibk3sfIIBhZchAhjoiaCQlficdtQTnEqYncy3GVEMPIOJwD7t0mO2KfYGMgkIg/0, createdBy=86081727811, createdName=4546wk, createdTime=Thu Jul 21 00:37:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93814, encodeId=ec589381480, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93815, encodeId=7dca938153b, content=继续关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-21 4546wk

    值得一看

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1887547, encodeId=8f1e188e54754, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Sep 11 16:21:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668386, encodeId=65fa16683863d, content=<a href='/topic/show?id=652641533df' target=_blank style='color:#2F92EE;'>#垃圾食品#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41533, encryptionId=652641533df, topicName=垃圾食品)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zGdN1x8J6HqtUI2Gpibk3sfIIBhZchAhjoiaCQlficdtQTnEqYncy3GVEMPIOJwD7t0mO2KfYGMgkIg/0, createdBy=86081727811, createdName=4546wk, createdTime=Thu Jul 21 00:37:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93814, encodeId=ec589381480, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93815, encodeId=7dca938153b, content=继续关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-20 doctorJiangchao

    继续学习

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1887547, encodeId=8f1e188e54754, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Sep 11 16:21:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668386, encodeId=65fa16683863d, content=<a href='/topic/show?id=652641533df' target=_blank style='color:#2F92EE;'>#垃圾食品#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41533, encryptionId=652641533df, topicName=垃圾食品)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zGdN1x8J6HqtUI2Gpibk3sfIIBhZchAhjoiaCQlficdtQTnEqYncy3GVEMPIOJwD7t0mO2KfYGMgkIg/0, createdBy=86081727811, createdName=4546wk, createdTime=Thu Jul 21 00:37:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93814, encodeId=ec589381480, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93815, encodeId=7dca938153b, content=继续关注，, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Wed Jul 20 13:03:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-20 doctorJiangchao

    继续关注，

    0

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Lancet：肥胖对男性寿命影响高于女性

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