J Allergy Clin Immunol:产前氧化平衡与哮喘和过敏性疾病风险在青少年中的研究

2019-09-03 AlexYang MedSci原创

胎儿的氧化平衡(保护性的产前因素抵消氧化应激源)可能对预防哮喘和过敏性疾病具有关键的作用。最近,有研究人员调查了产前摄入保护性的营养(包括抗氧化物)和潜在的氧化应激源情况对青少年哮喘和过敏性疾病的影响。研究包括了996对母亲-孩子。研究人员对孕妇怀孕前体重指数和产前营养素(维生素D、C和E、β-胡萝卜素、叶酸、胆碱、n-3和n-6多不饱和脂肪酸(PUFAs)的能量调节摄入)、空气污染物接触、对乙酰

胎儿的氧化平衡(保护性的产前因素抵消氧化应激源)可能对预防哮喘和过敏性疾病具有关键的作用。

最近,有研究人员调查了产前摄入保护性的营养(包括抗氧化物)和潜在的氧化应激源情况对青少年哮喘和过敏性疾病的影响。研究包括了996对母亲-孩子。研究人员对孕妇怀孕前体重指数和产前营养素(维生素D、C和E、β-胡萝卜素、叶酸、胆碱、n-3和n-6多不饱和脂肪酸(PUFAs)的能量调节摄入)、空气污染物接触、对乙酰氨基酚和吸烟进行调查。研究结果是子代哮喘、过敏性鼻炎和变应原致敏情况,年龄中值为12.9岁。研究发现,维生素D(对过敏性鼻炎,OR=0.69; 95% CI 0.53-0.89)、n-3 PUFAs EPA总量和DHA(对哮喘,OR=0.81, 95% CI 0.66-0.99)以及n-3 PUFAα亚麻酸(对过敏原敏感,OR=0.78; 95% CI 0.64-0.95)具有保护作用相关性。黑炭和PM2.5与过敏原敏感风险大约30%的提高相关。研究人员并没有发现保护性营养摄入与氧化应激源之间的乘性相互作用。

最后,研究人员指出,他们鉴定了产前的保护性营养(维生素D和n-3 PUFAs),以及产前的能够改变青少年哮喘和过敏性疾病风险的促氧化剂接触。

原始出处:

Sordillo JE, Rifas-Shiman SL, Switkowski K et al. Prenatal Oxidative Balance and Risk of Asthma and Allergic Disease in Adolescence. J Allergy Clin Immunol. 19 Aug 2019

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2019-09-05 膀胱癌
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    2019-09-05 qilu_qi