Ann Thorac Surg:上海胸科医院方文涛等发现胸腺鳞状细胞癌完全切除可使患者获益

2013-09-06 萧弈 DXY

胸腺鳞状细胞癌是罕见的恶性肿瘤,其外科治疗效果相关报道较少,临床和病理特点及影响预后的因素目前为止尚不确定。为此,来自中国上海胸科医院胸外科的方文涛教授等人进行了一项研究,研究结果在线发表于2013年7月15日的《胸外科年鉴》(Ann Thorac Surg)杂志上。研究发现,完全切除胸腺鳞状细胞癌可以预测更好的整体生存率,同时可延长术后无病生存时间。该研究纳入了2003年2月至2010年12月间

胸腺鳞状细胞癌是罕见的恶性肿瘤,其外科治疗效果相关报道较少,临床和病理特点及影响预后的因素目前为止尚不确定。为此,来自中国上海胸科医院胸外科的方文涛教授等人进行了一项研究,研究结果在线发表于2013年7月15日的《胸外科年鉴》(Ann Thorac Surg)杂志上。研究发现,完全切除胸腺鳞状细胞癌可以预测更好的整体生存率,同时可延长术后无病生存时间。
该研究纳入了2003年2月至2010年12月间在上海胸科医院进行手术治疗的105例患者,均经病理证实为胸腺鳞状细胞癌,回顾性分析其临床和病理资料。研究采用Kaplan-Meier和log rank检验进行生存分析,使用Cox回归模型进行多因素分析。【原文下载

研究结果发现,鳞状细胞亚型占胸腺癌的73.4%和胸腺肿瘤的16.1%。受试者5年总生存率和无病生存率分别为59.5%和57.6%。多变量分析中,只有完全切除(危险比3.692)对整体生存有显着影响。完全切除(危险比2.361)和化疗(危险比0.307)与无病生存率相关。

该研究结果表明,完全切除不仅可以预测胸腺鳞状细胞癌更好的整体生存率,还能够延长患者术后无病生存时间。该研究为特定的胸腺癌临床分期提供了更多证据。同时作者认为,Masaoka-Koga分期可能不是胸腺癌的独立预后因素。

原文下载

Zhao Y, Zhao H, Hu D, Fan L, Shi J, Fang W.Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases.Ann Thorac Surg. 2013 Sep;96(3):1019-24.

评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1978370, encodeId=f02419e837050, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Sep 24 15:10:00 CST 2013, time=2013-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663457, encodeId=64c4166345ee7, content=<a href='/topic/show?id=451a8418304' target=_blank style='color:#2F92EE;'>#胸腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84183, encryptionId=451a8418304, topicName=胸腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fcbd25619530, createdName=1508842480_96220445, createdTime=Sat Oct 19 22:10:00 CST 2013, time=2013-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056965, encodeId=9f79205696515, content=<a href='/topic/show?id=a19b1e4042f' target=_blank style='color:#2F92EE;'>#THORAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17404, encryptionId=a19b1e4042f, topicName=THORAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, createdName=yyj062, createdTime=Sun Mar 02 07:10:00 CST 2014, time=2014-03-02, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1978370, encodeId=f02419e837050, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Sep 24 15:10:00 CST 2013, time=2013-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663457, encodeId=64c4166345ee7, content=<a href='/topic/show?id=451a8418304' target=_blank style='color:#2F92EE;'>#胸腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84183, encryptionId=451a8418304, topicName=胸腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fcbd25619530, createdName=1508842480_96220445, createdTime=Sat Oct 19 22:10:00 CST 2013, time=2013-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056965, encodeId=9f79205696515, content=<a href='/topic/show?id=a19b1e4042f' target=_blank style='color:#2F92EE;'>#THORAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17404, encryptionId=a19b1e4042f, topicName=THORAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, createdName=yyj062, createdTime=Sun Mar 02 07:10:00 CST 2014, time=2014-03-02, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1978370, encodeId=f02419e837050, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Sep 24 15:10:00 CST 2013, time=2013-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663457, encodeId=64c4166345ee7, content=<a href='/topic/show?id=451a8418304' target=_blank style='color:#2F92EE;'>#胸腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84183, encryptionId=451a8418304, topicName=胸腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fcbd25619530, createdName=1508842480_96220445, createdTime=Sat Oct 19 22:10:00 CST 2013, time=2013-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056965, encodeId=9f79205696515, content=<a href='/topic/show?id=a19b1e4042f' target=_blank style='color:#2F92EE;'>#THORAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17404, encryptionId=a19b1e4042f, topicName=THORAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=052a130, createdName=yyj062, createdTime=Sun Mar 02 07:10:00 CST 2014, time=2014-03-02, status=1, ipAttribution=)]
    2014-03-02 yyj062