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CLIN CANCER RES：弥漫型胃腺癌KMT2C突变促进上皮间质转化

2018-12-23 MedSci MedSci原创

弥漫型胃腺癌KMT2C上皮间质转化
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劳伦弥漫型胃腺癌（DGAs）通常基因特征稳定。LIN CANCER RES近期发表了一篇文章，研究赖氨酸（K）特异性甲基转移酶2C（KMT2C）在DGAs中的突变情况及进展中的作用。

劳伦弥漫型胃腺癌（DGAs）通常基因特征稳定。LIN CANCER RES近期发表了一篇文章，研究赖氨酸（K）特异性甲基转移酶2C（KMT2C）在DGAs中的突变情况及进展中的作用。

作者对27例接受胃切除术的DGA患者的肿瘤样本进行了全外显子组测序。在DGA细胞系和患者肿瘤中分析KMT2C情况。研究结果表明，KMT2C是最常见的突变基因。通过免疫组化检测135例接受胃切除的DGA患者的肿瘤KMT2C表达情况，KMT2C表达与肿瘤分期较晚和总体生存率较差呈负相关。在HFE-145胃上皮细胞中通过KMT2C shRNA敲低KMT2C促进上皮-间质转化（EMT）。KMT2C敲低后胃上皮细胞的迁移和侵袭能力增加47-88倍。在无KMT2C表达的DGA细胞系MKN-45和SNU-668中，重新表达KMT2C可以降低EMT相关蛋白的表达，使细胞迁移能力减少52％至60％，并使细胞侵袭能力减少50％至74 ％。EMT可导致肿瘤干细胞（CSC）表型增加。DGA细胞系中重新表达KMT2C可以通过促进DNA损伤和凋亡逆转CSC化疗耐药。

文章最后认为，KMT2C在特定DGA人群中经常发生突变。DGA中的KMT2C缺失促进EMT并且与总生存较差有关。

原始出处：

Soo-Jeong Cho, Changhwan Yoon, et al. KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition. CLIN CANCER RES. December 2018 doi: 10.1158/1078-0432.CCR-17-1679

本文系梅斯医学（MedSci）原创编译整理，转载需授权！


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    2019-08-15 limedical1984

    #上皮间质转化#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1704945, encodeId=bf8d1e049455b, content=<a href='/topic/show?id=7b3c20040c8' target=_blank style='color:#2F92EE;'>#上皮间质转化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20040, encryptionId=7b3c20040c8, topicName=上皮间质转化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd9530903442, createdName=limedical1984, createdTime=Thu Aug 15 18:34:00 CST 2019, time=2019-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305926, encodeId=255f1305926f5, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Tue Dec 25 00:34:00 CST 2018, time=2018-12-25, status=1, ipAttribution=)]
    2018-12-25 xuruicheng

    #胃腺癌#

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